Introduction: The development of a plant derived supplement with mild effects and reduced toxic and side effects for the treatment of respiratory disease is very crucial. Therefore we tested the cough suppressant effects of three plant preparations that are made from Thymus gobicus Tczern, Thermopsis lanceolata L, Glycyrrhiza uralensis Fisch and Vaccinium Vitis idea/, plants that are common in our country. Materials and Methods:The research was conducted in 2013-2014 at the Pharmacological Laboratory of the Drug Research Institute. The experiment was carried out on four groups of 20 guinea weighing 300-400 grams and the experimental condition of coughing was generated using the method of Ucelay et al. Result:The results of the study show that the combination 3 (Thymus gobicus Tczern, Thermopsis lanceolata L, Glycyrrhiza uralensis Fisc, Vaccinium Vitis idea) had suppressed the most when compared to the other combinations.