Introduction: Number of kidney acute and chronic disease is increasing rapidly in the world and becoming the major cause of death even population employment capacity is invalid. Statistical report of Mongolian Ministry of Health last 5 years statistic kidney disease is in the 3rd of non contagious disease.Synthetic and chemical medicines used for this sort of disease would have side effects in some cases. Plants, animals and minerals biologically active substances, side effects need to produce new drugs, has attracted the attention of researchers. Goal: identifying pharmacology act of new granule medicine preparation. Materials and Ìethods: Experiment is on 4 kinds of 35 white rat, 150-280 gram WISTAR RAT. 5 rats from each kind. 1. Healthy group 2. Disease model group /Kanamycin+distilled water/ 3. Standard group / Kanamycin+nefromon/ 4. Experiment group / Kanamycin+ +new form of granule medicine/ Kidney disease model was created artificially kanamycin sulfate (Monodoev. A.J, Lameza.S.B, Bartonov. EA 1988) MDA is identified by an amount of concentration and method. (Stalinaya.I.D 1977) Result: Creatinine amount of disease model group of kidney illness created by kanamycin sulfate is compared with healthy group animals and 1.64 times, carbamide amount is 4.25 times, rest of the azotes 2.73 are increased and comparing the experiment group creatinine amount is 1.65 creatinine amount is 1.65 decreased comparing with disease model group. Conclution: When compound ingredients preparation creates experiment animal kanamycin sulfate oxidant dominates, intensify the kidney cell active, decrease the carbamide and creatinine and decrease the kidney cell necrosis. Key words: Kanamycin, Wistar rate, Iris Tenuifolia, Oxytropsis pseudoglandulosa, Ribes Diacanthum and Granule.