Abstract During the gallbladder calcifying disease, symptom of yellow-colored pustules was found on many of the patients’ both sides of the tongue and wet pustules on the tongues. The changes on the tongues were confirmed by ultrasound test and comparison with clinical diagnosis and photos were taken. These changes on the tongue are the major indications of gallbladder calcifying disease. Key words:Gallbladder calcifying, symptom of yellow-colored pustules, wet pustules tongue