No abstract available.
Wound Healing

In recent years, there is a growing enthusiasm in honey which has potential health benefits, disease prevention and serves as substitution of modern medicine. Honey is a natural sweet product which is produced by honey bees from floral nectar and has been traditionally used to treat several diseases such as cardiovascular disease, diabetes mellitus, cancer and Alzheimer’s disease since ancient times. Gelam honey (GH) is one of the Malaysian wild monofloral honey which is widely used as traditional medicine by the local population. GH is enriched with several therapeutic properties namely, antioxidative, antiinflammatory, anticancer and accelerated wound healing activities. However, there is lack of literature focusing on the overall effects of GH and its medicinal value. This review paper summarises the phytochemistry characteristics of GH along with its therapeutic values which lead to a broad spectrum idea on several diseases. A concise clarification on the therapeutic properties of GH is expected to provide new knowledge to thescientific society in these modern globalization eras.
Wound Healing

Objective: To evaluate the association of glycated haemoglobin (HbA1c) reduction and wound healing in patients with diabetic foot ulcer (DFU). Methodology: A 12-week prospective, non-controlled, interventional study in suboptimal-controlled T2DM patients with DFU was conducted. Antidiabetic medications were adjusted with the aim of at least 1% in relation to patient’s individualised HbA1c target. The wound area was determined by using specific wound tracing. The daily wound area healing rate in cm2 per day was calculated as the difference between wound area at first visit and the subsequent visit divided by the number of days between the two visits. Results: 19 patients were included in the study. There was a significant HbA1c reduction from 10.33 %+1.83% to 6.89%+1.4% (p<0.001) with no severe hypoglycaemia. The median daily wound area healing rate was 0.234 (0.025,0.453) cm2/day. There was a strong positive correlation between these two variables (r=0.752,p=0.01). After dividing the patients into four quartiles based on final HbA1c and comparing the first quartile vs fourth quartile, there was a significant difference in daily wound area healing rates (0.597 vs 0.044 cm2/day,p=0.012). Conclusion There was a positive correlation between HbA1c reduction and wound healing rate in patients with DFU. Although this is an association study, the study postulated the benefits of achieving lower HbA1c on wound healing rate in DFU which require evidence from future randomised controlled studies.
Wound Healing

No abstract available.
Wound Healing* ; Wounds and Injuries*

No abstract available.
Wound Healing* ; Wounds and Injuries*

Many clinicians expect complete healing after the removal of temporary anchorage devices, but clinical examination may reveal scar-like tissue. This report presents the typical features of scarring detected after the removal of miniscrews, and the clinical outcome of scar revision along with its pathologic features.
Cicatrix* ; Wound Healing

As the dressings currently used in clinic settings unflat shape in general, they can't be fitted completely on occiput, heel, elbow, knee and other body parts unflat. This paper developed one kind of foam dressing of special shape based on local anatomy. The foam dressing is waterproof and air permeable, it can cover the wound closely enough to prevent bacteria from invasion and infection. With a saturated absorption ratio of 1: 8 or higher, it can keep the wound clean and moisture by absorbing large amounts of wound inflammatory secretions and is almost completely permeable to oxygen and carbon dioxide. Assuring safety and effect meanwhile, it has better outcomes than common dressings in the same application settings.
Bandages ; Wound Healing

No abstract available.
Wound Healing* ; Wounds and Injuries*

Objectives. The purpose of this study was to evaluate the antimicrobial and wound healing property of the preformulated hydrogel containing the methanolic leaf extract of Ixora coccinea, as well as its acute dermal irritation using New Zealand rabbits.

Methods. Mature dried leaves of I. coccinea was subjected to extraction using maceration and was concentrated in vacuo. Sodium carboxymethylcellulose and gelatin were used to create hydrogel in which the crude extract was incorporated. Physicochemical properties of the extract and preformulated hydrogel were characterized, while its antimicrobial activities against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis were determined using the agar well method and compared to the standard drug 2% w/v mupirocin ointment. A wound excision model in rats was used to determine the wound healing property of the preformulated hydrogel against povidone-iodine ointment. Lastly, animal testing was performed following the OECD Guidelines and upon approval of the IACUC Committee.

Result. The preformulated hydrogel was effective against S. aureus (p-value ? 0.001) but resistant to P. aeruginosa and S. epidermidis. Furthermore, the wound contraction rate in groups treated with preformulated hydrogel (p-value = 0.006) is significantly higher than in groups treated with hydrogel base and povidone-iodine. Moreover, no dermal erythema and edema were observed with albino rabbits.

Conclusion. The preformulated hydrogel with I. coccinea methanolic leaf extract is non-irritating, effective against staphylococcal infections commonly found in wounds. Hence, it is a good substitute for povidone-iodine in wound treatment.

The substitute materials of autologous tissue graft for periodontal soft tissue augmentation surgery develop rapidly. The use of substitute material can avoid the second operation area, shorten the operation time, reduce the postoperative reaction and pain, and is not limited by the quantity, suitable for a wide range of cases. In this paper, the characteristics, histological study, clinical application and therapeutic effect of acellular dermal matrix as a substitute material for autologous tissue transplantation were introduced to provide reference for clinical work.
Acellular Dermis ; Wound Healing