This study was conducted to examine the effect of chronic low dose organic solvent exposures in the industries towards then neurobehavioral functions of workers subjective symptoms on neurobehavioral function as well as a visual reaction time test (Flicker test) were administered to 94 exposed and 162 unexposed workers in a oil refinery and some other auto-repair shops. The results obtained were as follows: 1. Symptom complaints were higher and Flicker test values were lower in exposed workers than in unexposed workers. 2. Flicker values were inversely correlated with urinary Hippuric acid concentration in exposed workers (r=-0.26, p<0.05). 3. Flicker values were inversely correlated with subjective symptom score (r=-0.15, p<0.05). Low Flicker value were also related with some subjective symptoms such as "Dimmed vision", "Nightmare", "weakness on extremity" in workers as a whole. While symptoms of "Dimmed vision", "Nightmare" only observed among exposed workers.
Reaction Time

This study aims to investigate visual tracking task of Koreans to the various visual stimuli by measuring the horizontal saccadic reaction times. The measuring system consists of eye monitor using infra-red reflection technique, oscillographic recorder and forehead-chin fixation devices. The visual stimuli generated by target function generator displayed simple-step, pulsestep and double-step stimulus patterns. The results revealed that the sacoadic reaction time showed no significant changes between the size of target displacement within horizontal 20 degrees. Furthermore, no significant changes between the particular direction of stimulus could be found. The nominal value of reaction time was 259 +/- 25 msec.
Reaction Time

Objective. This is a cross-sectional study aimed to determine the time intervals from the first symptom to surgery of 37 patients with ovarian malignancies who underwent surgery at a tertiary government hospital from June to October 2019.

Methods. Structured interviews of patients and chart reviews were conducted to identify the intervals and the reasons behind such. The data were analyzed using Stata/SE 14.1, with the time intervals presented as medians and the reasons as frequencies. Multinomial logistic regression analysis established the association of time intervals with the extent of surgery and final stage of ovarian malignancies.

Results. The median Total Time Interval from the first symptom to surgery was 214 days. The longest delay was the Total System Interval (from the first visit at the tertiary hospital to surgery) with a median of 70 days. This was followed closely by Patient Interval (from the first symptom to consult with the initial physician) with a median of 64 days. A distant third was the Initial Physician Interval (from the consult with the initial physician to the first visit at the tertiary hospital) with a median of 29 days. Most common reasons for the delays were the patients not acknowledging the gravity of their condition for the Patient Interval; choice to go to other hospitals, distance and laboratory works or diagnostics for the Initial Physician Interval; waiting for laboratory work-ups for the First System Interval; and waiting for other departments' clearance for the Second System Interval. The most common first symptom was abdominal enlargement. The length of interval and the final stage (p=0.056 for Stage III and p=0.162 for Stage IV)) as well as extent of surgery (p=0.093) did not show significant association.

Conclusion. The time interval from first symptom to surgery showed a median of 214 days. The greatest delay is contributed by Total System Interval followed by Patient Interval due to varying reasons. Length of time intervals, however, was not found to be significantly associated with the extent of surgery and final stage

Introduction: To date, there are no reference intervals for prothrombin time (PT) and activated partial thromboplastin time (APTT) based on “normal” Filipino adults. The common practice in most laboratories is to adopt manufacturer provided values or foreign literature even if the importance of establishing or at least verifying laboratory reference intervals has been stressed by Clinical Laboratory Standards Institute (CLSI). Objectives: Here we aim to describe our experience in using a simple non-parametric method to generate reference intervals for PT and APTT, from healthy Filipino volunteer blood donors. Methodology: We used a de novo, a priori non-parametric estimation method following the CLSI guidelines on establishing reference intervals. Results: The non-parametric lower reference limit for PT is 12.55 seconds, with 90% confidence interval of 12.3 to 12.75 seconds. While the non-parametric upper reference limit for PT is 16.15 seconds, with 90% confidence interval of 15.55 to 16.55 seconds. The non-parametric lower reference limit for activated partial thromboplastin time is 26.12 seconds, with 90% confidence interval of 22.95 to 27.1 seconds, and the non-parametric upper reference limit for activated partial thromboplastin time is 37.44 seconds, with 90% confidence interval of 36.75 to 38.65 seconds. The PT and APTT reference intervals were different from foreign sources and manufacturer provided values in terms of interval width and values of the reference limits by 2 to 4 seconds. Conclusion and Recommendations Estimation of coagulation reference intervals from volunteer health blood donors is doable, simple, and practical. Collaborative multi-center efforts may be done to expand the pool of reference individuals that are included and increase the representativeness of the reference intervals generated. This simple method can also be used to generate reference intervals for other clinical laboratory assays and may also be extended to at least verify reference intervals in special populations like pregnant women, the elderly, and the pediatric population.
Prothrombin Time ; Partial Thromboplastin Time

Humans ; Physiological Phenomena ; Qi ; Time ; Time Factors

OBJECTIVES: This study was conducted to examine the effect of blood mercury on neurobehavioral performance in Korean elementary school students. METHODS: We measured the blood mercury concentration in 1,077 elementary school students from Seoul, Busan, Daegu and Gwangju, then the students underwent computerized neurobehavioral test. RESULTS: The mean concentration of blood mercury of study subjects was 2.10 microg/L. An increased blood mercury was associated with an increased reaction time in digit addition and symbol digit. CONCLUSIONS: The blood mercury concentration of study subjects was very high compared to findings in a foreign country. We found several associations between blood mercury level and neurobehavioral performance.
Humans ; Reaction Time

15 parkinsonian patients with mainly unilateral symptoms (right side 10, left side 5) were studied in a decision reaction time (DRT) experiment in which the performance of the more affected hand was compared with that of the less affected hand. Decision time (DT) was longer in the more affected hand, however, the movement time (MT) did not differ between the two hands. In conclusion, slowness of movement in complex reaction response in Parkinsonian patients may be attributable to the defect of premovement central neural processing related to motor planning.
Hand ; Humans ; Reaction Time

Study on 730 pregnant women with oligohydramnios, among 10,663 normal pregnancies at National Obstetrics and Gynecology Hospital in 2002. In 250 pregnant women with oligohydramnios there were 66.4% had cesarian section, 31.6% had normal childbirth and 4% had an extra option under childbirth, the amniotic fluid volume depended on gestational age, from 30 weeks, amniotic fluid volume decreased with the speed about 33% per one week. Amniotic fluid volume associated with the condition on health of fetus. Now using the ultrasound to evaluate the amniotic fluid volume by two techniques: the maximal vertical pocket and the amniotic fluid index
Fetus ; Oligohydramnios ; Time Factors

PURPOSE: The purpose of this study is to evaluate the clinical and radiologic results of using Acutrak screws for treating ankle medial malleolar fracture. MATERIALS AND METHODS: We reviewed 38 cases of ankle medial malleolar fracture treated with Acutrak screws from February 2005 to May 2008. RESULTS: In clinical result, there were 30 exellent cases, 7 good cases, 1 fair case. In radiologic result, there is no case with reduction loss. Average union time is 10.5 weeks. CONCLUSION: We conclude that Acutrak screw fixation is a useful method for ankle medial malleolar fracture, there are many advantages in accurate anatomical reduction, small incision, short operative time.
Animals ; Ankle ; Operative Time

The strains of JE vaccine were produced from Nakayama strain: S461, S462, S463 and from Beijing-1 strain: BS0704, BS0804, BS0904. The content of formalin for inactivation was 0.06% at 40C. The schedule for testing: 0, 3, 7, 14, 21, 28 and 35 days. The crude virus was inoculated directly into IC 0.03 ml/mouse then followed up within 14 days. Calculated LD50 according to Reed and Muench method. Results: LD50 decreased step by step and LD50 = 0 at the 28th days. That means from 28th days, crude vaccine which was produced from Nakayama and Beijing-1 strains were completely inactivated.
Encephalitis, Japanese ; Time Factors