Nine compounds derivated from 2-mercaptobezothiazole were synthesized. Their structure have been identified by MS-, IR-, and UV- spectroscopy. Antimicrobial activities of some compounds have been tested. Hydrazide BT6 and substituted hydrazides BT7, BT8, BT9 were found to have significant inhibitory activity on P. aeruginosa, S. aureus, Asp. niger and F. oxysporum at concentration 50mcg/ml.
Pharmaceutical Preparations

Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.
Pharmaceutical Preparations

According to the results of an investigation on 270 households in May 1999 carried out in Tien Son district, Bac Ninh province, 56 (20.79%) purchasing households came to commune health centre, 195 (72.22%) came to private clinic, 8 (2.96%) came to public pharmacy and 11 (4.03%) came to private pharmacy. Quality of the drug, easiness to access, reasonable price, good counseling... are the favorable factors to promote the purchaser's choice
Pharmaceutical Preparations ; Pharmaceutical Services

Chlorpheniramine meleate (CM) is a antihistaminic agent. Assay for chlorpheniramine meleate in the multi-component drugs by colorimetry method. A technique was proposed to increase the accuracy of the assay for chlorpheniramine meleate. The assay of the method is about 2%
Chlorpheniramine ; Pharmaceutical Preparations ; Colorimetry

Using beta-blocker propranolone immediately after electric shock helped successful treatment in 2 female patients, 21 years old and 27 years old, who experienced schizophrenia (F20) and had treated by antidepressant drugs. After treatment, both of them were stable and only used drugs at median dose. After electric shock they ate and slept well, had stable behaviour, and pulse was 80-90 c/m. Patients discharged after 1 week
Depression ; Defibrillators ; Pharmaceutical Preparations

The capacity of dissolution of active component of the tablet of ciproflaxacin. 6 samples composing of 78 domestic and foreign ciprofloxacin tablet were tested. Results showed that 2 of 3 samples of domestic tablet did not meet the requirement for dissolution mentioned to USP XXIII, while the foreign tablets manifested a rate of dissolution higher than that of pharmacopea
Ciprofloxacin ; Pharmaceutical Preparations ; Tablets

Basing on common chemical reactions, thin layer chromato graphy, absouptive ultraviolet spectrum some parameters were determined for preparation containing benzodiazepine in HCM City. The efficiency of extraction of benzodiazepan in 6 self made sample: Rhino sweet drink, coca-cola, combined food, soya milk, 333 beer and urine. Results found 17 active substances of diazepine group in 131 specialities of commercial propriatary name in HCM City, where diazepam had accounted higher rate in narcotic intoxixation cases. In criminal cases involved in tranquillisant narcotics, the most common substance were diazepan, flunitrazepan, clonazepan, bromazepan, alprazolam, clorazepat, oxazepan and nor-diazepan
Benzodiazepines ; Pharmaceutical Preparations ; Chemistry

The opening, comparing results before and after treatment clinical trial was performed to abserve the effects of Weitai 999 (an oriental medicine imported from China) on 60 patients with chronic gastritis, were treated by 500 mg of Weitai 999, 4 tablets a day for 30 days. The results showed that 81.2% of patients did not have upper abdominal pain. Endoscopy showed 71.7% of patients had not gastric mucosal inflammation after treatment. Histopathology showed good effect on activity of inflammation in 75.4% of patients. The rate of HP eradication was 34.5%. There was not clinical side effects
gastritis ; Therapeutics ; Pharmaceutical Preparations

Artesunat at doses of 50 mg/kg the first day and 25 mg/kg per day for four following days had no effect to the birth progress of P, F1 and F2. Concretely: No coffuse birth: ratio of conjugation, conception, early died feotus and late died feotus among P, F1 and F2 were similar, and were not higher than control group. No innate defects in born mice from P, F1 and F2. Quantity and weight of mice were in normal, and were not different with the control group
Artemisinins ; Pharmaceutical Preparations ; Therapeutics

The researchers built targets and way to handle skin and built quantitative method notroglucerin by high-performance liquid chromatography (HPLC) and quantitative method total nitroglucerin content in sticking-plaster Discotrin 36mg with area of 13,3cm2. The study was carried out in 6 samples and average with RSD = 0,47%, from there find out exactly nitroglycerin level on 1cm2 to evaluate permeation of nitroglycerin through skin in different temperatures ( 41oC, 37oC, 25oC). The result showed that the higher temperature, the more Nitroglycerin is permeated. The permeation of nitroglycerin through skin is defferent in each animal
Nitroglycerin ; Pharmaceutical Preparations ; Skin