Nine compounds derivated from 2-mercaptobezothiazole were synthesized. Their structure have been identified by MS-, IR-, and UV- spectroscopy. Antimicrobial activities of some compounds have been tested. Hydrazide BT6 and substituted hydrazides BT7, BT8, BT9 were found to have significant inhibitory activity on P. aeruginosa, S. aureus, Asp. niger and F. oxysporum at concentration 50mcg/ml.
Pharmaceutical Preparations

Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.
Pharmaceutical Preparations

According to the results of an investigation on 270 households in May 1999 carried out in Tien Son district, Bac Ninh province, 56 (20.79%) purchasing households came to commune health centre, 195 (72.22%) came to private clinic, 8 (2.96%) came to public pharmacy and 11 (4.03%) came to private pharmacy. Quality of the drug, easiness to access, reasonable price, good counseling... are the favorable factors to promote the purchaser's choice
Pharmaceutical Preparations ; Pharmaceutical Services

Antimalarial drug samples were collected from different parts of the country for quality investigation in 2004. A total of 129 samples of different batches were collected at three rounds and cross-checked at local, central level and abroad. At the round one, three out of 49 collected samples were found substandard. One of 40 samples of the second round was determined counterfeit (2.5%). The re-analysis of 51 samples at NIDQC revealed two from the first round were substandard and one from the second round was counterfeit
Malaria ; Therapeutics ; Pharmaceutical Preparations

Study on 2 drugs of combined components: The drug number 1: combined tablets of Ethambutol/Isoniazide 400/150mg; The drug number 2: combined tablets of Rifampicine/Isoniazide 150/100mg and Pyrazinamide 500mg. These drugs delivered from India to Vietnam by the airway or shipment during April 2001 to September 2003. The results showed that: delivering time was approximately 10 days in airway and estimated time of 32 days in shipment. The time for issuing Vinacontrol's cerfiticate on drug quality was approximately 348 days, the time for issuing certificate on drug quality was longer than delivering time both the airway and the shipment. The results of testing drug quality before and after delivering pharmaceutical drugs from India to Vietnam found that testing indicators excepted assays were as same in certificate of manufacturer, SGS International and Vinacontrol and assay of imported drugs was in rank of registered standards
Pharmaceutical Preparations ; Tablets ; Vietnam

Through pH determination, acide- color quantification, extraction time and stabilization time of solvent extracting layer, optimal parameters were determined to quantify loperamide. The method could have high sensitive and selectivity with precise and repetitive results; its is appropriate for laboratories at low level of technique equipments
Loperamide ; Pharmaceutical Preparations ; Laboratories

The reality, some results and shortcomings of privatization process of state owned pharmacies were evaluated at period 1999-2003. The result: privatizating state owned pharmacies is relatively good, the amount of privatizated state owned pharmacies increase continously in past years. However, although there were 54,1% of provinces and cities implementing privatization but mainly that are enterprises belong to 2 regions of The Red river delta and South- East Viet Nam. This showed that the privatization process of regions isn’t equal. According to the plan, in 1998 there had been 7 units carrying out privatization but to the end of the 2000, there was only 1 first unit conversing successtly. That is the branch of Hai Phong 1 Health company changing into HaiPhong Health trade privatization company. Estimating to 12/2003, there were 8 center state owned pharmacies and 65 local state owned pharmacies privatized. They concentrate most in South VietNam
Pharmacies ; Pharmaceutical Preparations ; Epidemiology

Forecast during 10 years from 2005 to 2014, the numbers of chemical drugs whose intellectual ownership will be expired are 83 substances with their turnover of over 100 billion USD. These are main substances that used for treating chronic diseases among non-communicable diseases - a disease pattern in the developed countries and industrializing countries, which Vietnam is one of them. To study about exploit coming to meet chemical drugs whose intellectual ownership will be expired, many generic manufactories have built research – development strategy in order to produce some specific generic groups, avoiding the simple “copy” of the formula and forms of available brand name products
Pharmaceutical Preparations ; Therapeutics ; Disease

Report one case of male patient aged 50 years old admitted Pham Ngoc Thach Hospital on August, 23rd 2004 due to allergic reactions with 2 main anti TB rifampicin and isoniazid. He was treated by conventional desensitization to rifampicin and isoniazid. After that, he was treated by formula of 2RHZE/6HE (+ Rifampicin) in 8 months, with good outcomes. X-ray finding on September, 27th 2004 and on May, 27th 2005: pleural effusion decreased and stopped, less pleural adhesion
Tuberculosis ; Therapeutics ; Pharmaceutical Preparations

Quality of the locally produced artesunate 50mg tablets provided by the National Malaria Control program to five provinces of Cao Bang, Bac Kan, Ha Tinh and Ninh Thuan was monitored in a survey from June 2001 to December 2004 that was conformed with the expiry date of the drug. The drug had also been previously found to meet the quality criteria of manufacturer and pharmacopoeia. Analysis of samples collected from five provinces showed a remaining stable quality of mass equability, disintegration, hardness and solubility as permitted limits. The artesunate concentration was found to be 90-100% and 95-105% according to pharmaceutical classes and manufacturer criteria, respectively
Malaria ; Pharmaceutical Preparations ; Artemisinins