1.The effects of antibiotics on phagocytosis and bacterial morphology.
Duk Han KIM ; Mi Gyeong KIM ; Min Jung KIM ; So Gyem YOON ; Yung Bu KIM ; Yang Hyo OH
Journal of the Korean Society for Microbiology 1993;28(3):183-192
No abstract available.
Anti-Bacterial Agents*
;
Phagocytosis*
2.Advancements in the study of the classification and immune function of shrimp hemocytes.
Chinese Journal of Biotechnology 2021;37(1):53-66
Hemocytes play an important role in the immune defense system of animals, especially for invertebrates that have no adaptive immune system. In those animals, hemocytes not only participate in the cellular immunity including phagocytosis, encapsulation, and nodules formation, but also the humoral immunity via storage and release of immune factors. Identification of the components of hemocytes is the basis for understanding the immune mechanism and the function of hemocytes. Despite various researches have been done on distinguishing the composition and function of shrimp hemocytes, no standard is used uniformly until now. So, we analyze and summarize the results on shrimp hemocytes research and offer a three subgroups category in this review. We also introduce the morphological characters and immune function of three subgroups in detail. We hope this work will be beneficial for understanding the function and molecular mechanism of hemocytes in invertebrate, bringing ideas for new separation technology development.
Animals
;
Hemocytes
;
Phagocytosis
3.The effect of chemotherapeutic agents on phagocytosis of polymorphonuclear leukocytes in patients with gastric cancer.
Jong Ho WON ; Dong Gib RA ; Jun Hee WOO ; Dae Sik HONG ; Hee Sook PARK ; Hi Bahl LEE
Journal of the Korean Cancer Association 1992;24(2):249-255
No abstract available.
Humans
;
Neutrophils*
;
Phagocytosis*
;
Stomach Neoplasms*
4.Effects of ascorbic acid on the phagocytosis of murine peritoneal macrophages and the activities of lymphocytes.
Sang Ik LEE ; Young Jun KANG ; Ga Jin JEONG
Korean Journal of Immunology 1993;15(2):217-225
No abstract available.
Ascorbic Acid*
;
Lymphocytes*
;
Macrophages, Peritoneal*
;
Phagocytosis*
5.In vitro effects of some antifungal agents on the chemotaxis and phagocytosis response of human neutrophils.
Jung Hyun CHOI ; Yang Rhee KIM ; Dong Heon KANG ; Won Oh CHOO ; Si Young YANG ; Wan Shik SHIN ; Moon Won KANG
Korean Journal of Infectious Diseases 1991;23(4):265-270
No abstract available.
Antifungal Agents*
;
Chemotaxis*
;
Humans*
;
Neutrophils*
;
Phagocytosis*
6.Microglial Phagocytosis in the Neurodegenerative Diseases.
Sheng-nan CAO ; Xiu-qi BAO ; Hua SUN ; Dan ZHANG
Acta Academiae Medicinae Sinicae 2016;38(2):228-233
Microglia are the resident innate immune cells in the brain. Under endogenous or exogenous stimulates, they become activated and play an important role in the neurodegenerative diseases. Microglial phagocytosis is a process of receptor-mediated engulfment and degradation of apoptotic cells. In addition, microglia can phagocyte brain-specific cargo, such as myelin debris and abnormal protein aggregation. However, recent studies have shown that microglia can also phagocyte stressed-but-viable neurons, causing loss of neurons in the brain. Thus, whether microglial phagocytosis is beneficial or not in neurodegenerative disease remains controversial. This article reviews microglial phagocytosis related mechanisms and its potential roles in neurodegenerative diseases, with an attempt to provide new insights in the treatment of neurodegenerative diseases.
Humans
;
Microglia
;
cytology
;
Neurodegenerative Diseases
;
physiopathology
;
Phagocytosis
7.Developments of neutrophil function and the relationship between neutrophils dysfunction and periodontitis.
Yue-jiao LIU ; Yiying LIU ; Yi XU
West China Journal of Stomatology 2016;34(2):210-214
Polymorphonuclear neutrophil leukocyte (PMN) is an important member of the human immune cells. Recentyears, the recognition of the PMN function and the relationship between PMN and periodontitis have been updated. Besidesthe pathogens killing and phagocytosis, PMN also play an important role in immunoregulation and proresolving. The maintaining of PMN homeostasis is an intricate process and the precondition of defense function, which involves activation, adhesion, recruitment, apoptosis and efferocytosis. The regulatory mechanism of PMN homeostasis called neutrophil rheostat, it works through several cytokines and cells. Any factors that break the homeostasis will result in the damage of host immunity,and may relate to the occurrence of periodontitis. Moreover, PMN dysfunction, because of host factors or microorganism factors, is closely related to periodontitis, especially those associated with systemic diseases and gene defect.
Cytokines
;
Homeostasis
;
Humans
;
Neutrophils
;
Periodontitis
;
Phagocytosis
8.Research Progress of Desialylation in Immune Thrombocytopenia -Review.
Jing-Yao MA ; Zhen-Ping CHEN ; Hao GU ; Ling-Ling FU ; Run-Hui WU
Journal of Experimental Hematology 2018;26(3):928-932
Some patients diagnosed as immune thrombocytopenia(ITP) have poor response to common first-line therapy such as corticosteroid and immunoglobulin. Studies in recent years have found a FC-independent platelet clearance pathway exists, which is characterized by desialylation of platelet surface glycoprotein(GP), recognition and phagocytosis by Ashwell-Morell receptor(AMR) on hepatocytes, independent on Fc receptors of the reticuloendothelial system. The up-regulation of neuraminidase-1(Neu1) expression on platelet caused by various factors, such as cold storage of platelet, septicemia and ITP could desialylate GPs. It has been found that ITP with positive anti-GPIbα antibody mostly has a poor response to first-line therapy and indicated that such antibody may lead to FC-independent platelet clearance. It also has been proved that anti-GPIbα antibody could desialylate GPs on platelet in animal experiments. Researchers have tris to use sialidase inhibitor agent to treat ITP and got a persistent response of platelet. Here, the desialylation of platelet and its role in ITP pathogensis and therapy are reviewed.
Animals
;
Antibodies
;
Blood Platelets
;
Humans
;
Phagocytosis
;
Thrombocytopenia
9.Astrocyte-Mediated Myelin Phagocytosis in Ischemia.
Luodan YANG ; Dongyu ZHANG ; Quanguang ZHANG
Neuroscience Bulletin 2023;39(1):167-169
Humans
;
Myelin Sheath
;
Astrocytes
;
Phagocytosis
;
Macrophages
;
Ischemia
10.Research progress on the effect of mitochondrial network remodeling on macrophages.
Lianlian ZHU ; Xiangmin KONG ; Wei ZHU
Chinese Journal of Cellular and Molecular Immunology 2023;39(7):656-662
Remodeling of the mitochondrial network is an important process in the maintenance of cellular homeostasis and is closely related to mitochondrial function. Interactions between the biogenesis of new mitochondria and the clearance of damaged mitochondria (mitophagy) is an important manifestation of mitochondrial network remodeling. Mitochondrial fission and fusion act as a bridge between biogenesis and mitophagy. In recent years, the importance of these processes has been described in a variety of tissues and cell types and under a variety of conditions. For example, robust remodeling of the mitochondrial network has been reported during the polarization and effector function of macrophages. Previous studies have also revealed the important role of mitochondrial morphological structure and metabolic changes in regulating the function of macrophages. Therefore, the processes that regulate remodeling of the mitochondrial network also play a crucial role in the immune response of macrophages. In this paper, we focus on the molecular mechanisms of mitochondrial regeneration, fission, fusion, and mitophagy in the process of mitochondrial network remodeling, and integrate these mechanisms to investigate their biological roles in macrophage polarization, inflammasome activation, and efferocytosis.
Mitochondria
;
Mitophagy
;
Homeostasis/physiology*
;
Phagocytosis
;
Macrophages/metabolism*