Objective To investigate the influencing factors for white matter hyperintensity （WMH） in middle-aged and elderly patients with hypertension， and to establish and verity a nomogram prediction model. Methods A total of 198 middle-aged and elderly patients with hypertension and WMH who were hospitalized in our hospital from January 2022 to April 2023 were enrolled. Related clinical data were analyzed， and related data were recorded. A binary logistic regression analysis was used to investigate the independent risk factors for WMH and establish a nomogram， and the receiver operating characteristic （ROC） curve and the calibration curve were used to evaluate the diagnostic efficacy of the nomogram. Results Age， course of hypertension， cystatin C， homocysteine，red blood cell distribution width， and cognitive impairment were the independent influencing factors for WMH in the middle-aged and elderly patients with hypertension. The nomogram established showed good diagnostic efficacy （AUC=0.815， 95% CI 0.756~0.874，P<0.001） and calibration ability （C index=0.794）. Conclusion The nomogram established in this study has a good predictive ability for moderate-to-severe WMH in middle-aged and elderly patients with hypertension and can provide certain help for clinical workers.
Nomograms

Objective To investigate the risk factors for early neurological deterioration in mild acute ischemic stroke，to construct a clinical predictive model，and to perform internal validation of this model. Methods A retrospective analysis was performed for 739 patients with mild acute ischemic stroke who were admitted to Department of Neurology，Kuntong Hospital of Zunhua，from October 2020 to December 2023，and they were randomly divided into a training set with 534 patients （72.3%） and a validation set with 205 patients （27.7%） at a ratio of 7∶3. Univariate and multivariate logistic regression analyses were performed for the training set to determine the risk factors for early neurological deterioration in mild acute ischemic stroke. A clinical predictive model was constructed，and internal validation was performed in terms of discriminatory ability，calibration，and clinical decision making. A nomogram was plotted. Results The multivariate logistic regression analysis showed that female sex （OR=1.87，95% CI 1.14~3.09，P=0.014），time window ≤6 hours （OR=3.10，95%CI 1.56~6.19，P=0.001），a baseline NIHSS score of 2 points （OR=3.72，95%CI 1.30~10.61，P=0.014），a baseline NIHSS score of 3 points （OR=4.24，95%CI 1.45~12.35，P=0.008），a TOAST classification of large artery atherosclerosis （OR=3.88，95%CI 2.20~6.83，P<0.001），and the responsible arteries of the basilar artery，the middle cerebral artery，and the internal carotid artery （OR=8.39，95%CI 2.28~30.85，P=0.001； OR=6.22，95%CI 1.78~21.71，P=0.004； OR=5.38，95%CI 1.15~25.13，P=0.032） were independent risk factors for early neurological deterioration in mild acute ischemic stroke. The clinical predictive model constructed showed a moderate discriminatory ability （AUC>0.7），good calibration （P>0.05） in the Hosmer-Lemeshow goodness-of-fit test），and good clinical benefits in both the training set and the validation set. Conclusion This clinical predictive model can effectively predict the onset of early neurological deterioration in mild acute ischemic stroke and guide clinicians to make decisions，and therefore，it holds promise for clinical application.
Nomograms

Sixteen normal subjects were tested with the Titmus stereotest varying the binocular Snellen's visual acuity from 1.0 to 0.2. From 15 possible combinations, a nomogram describing the relationship of binocular variations of Snellen's visual acuity and stereoacuity was constructed and the relationship of binocular isoacuities to Titmus stereotest performance was expressed as an S-shaped function.
Nomograms ; Telescopes ; Visual Acuity*

Bed-side measurement of Vd/Vt has not been used clinically, because the measurement of Pico2 in using the Bohr equation is complicated and a time-consuming test. A new, simplified and time-saving, bed-side calculation of Vd/Vt by using the Radford nomogram has been developed. In order to verify the method of calculated Vd/Vt, we compared the two methods(measured versus calculated Vd/Vt) in 20 open heart patients. Two methods had direct correlationship(y=0.95X+0.04) with r=0.864, and so the authors considered that the calculating method in the measurement of Vd/Vt is advantageous in clinical use.
Heart ; Humans ; Nomograms

The uroflowmetry was accurate, noninvasive method in the assessment of infravesical obstruction, but it was difficult to differentiate normal from obstructed individuals. The use of the flow rate nomogram appeared to differentiate reliably normal from obstructed individuals. The uroflowmetries using flow rate nomogram which was previously reported by our hospital, were performed on 35 BPH patients, 12 patients preoperatively and postoperatively (Group I) and 23 patients postoperatively only due to preoperative urinary retention (Group 2). The following results were obtained. 1. In group 1, the mean preoperative maximal flow rate was 9.4 (ml/sec) and the mean postoperative maximal flow rate was 15.3 (ml/sec). 2. In group 2, the mean postoperative maximal flow rate was 18.3 (ml/sec) 3. In group 1, nine of twelve patients (75%) were improved in the maximal flow rate. But six of twelve patients (50% ) were improved in the flow rate nomogram. 4. In group 2, fourteen of twenty-three patients (70%) were improved in the flow rate nomogram. In summary, this study shows much difference in the results between maximal flow rate and flow nomogram. So uroflowmetry using flow rate nomogram, we consider, will show more objective result in the evaluation of prostatectomized patient.
Humans ; Nomograms* ; Prostatectomy* ; Urinary Retention

PURPOSE: Peak urinary flow rate is a widely used parameter in the diagnosis and evaluation of treatment erect of BPH because of its objectiveness and non-in vasiveness. The peak urinary flow rate, however is different with each voided volume in the same patient and tends to decrease even in an asymptomatic man with increasing ages. Therefore we need an adjusted peak urinary flow rate corresponding with the age and voided volume. This adjusted peak urinary flow rate can be used to evaluate the voiding function more easily in the same patient periodically or In the different patient of various voided volume and ages. MATERIALS AND METHODS: Data on age, volume voided and peak urinary flow rate were accumulated from 216 male aged from 10 to 80 who were free of voiding symptoms. All combinations of peak urinary flow rate, age and volume voided were tested for equation of bet fit by the least squares method with search for the equation providing least residual standard deviation with SAS package. RESULTS: When the peak urinary flow rate is defined as a function of age and voided volume, the equation is Q=35.01+0.086A-0.0031A2-1612/V(Q: peak urinary flow rate, A: age, V: voided volume). At the point of population means for volume voided(247.5ml) arid age(35.2) the reference peak urinary flow rate was 27.7m1/sec. Adjusted peak flow rate can be obtained by subtracting the difference between the measured and expected peak flow rate(expected minus measured) from the reference peak flow rate. To make the adjusted peak flow rate obtained easily with measured peak flow rate, age and voided volume nomogram that incorporates the equation has been designed. In our nomogram an adjusted peak flow rate < 19.9 ml/sec or > 1.3 standard deviation below mean should be considered suspicious for obstruction. CONCLUSIONS: Nomogram for adjusted peak flow rate that incorporates the age, voided volume and measured peak flow rate would be satisfactory for clinical use.
Diagnosis ; Humans ; Least-Squares Analysis ; Male* ; Nomograms

The Korean 218 normal eyes, 74 myopic eyes and 42 glaucomatous eyes were examined. The intraocular pressure were measured by Goldmann applanation tonometer and Schiotz indentation tonometer using the 5.5 gm plunger load successively. The occular rigidity was estimated from Friedenwald 1955 nomogram. In normal eyes, the average coefficient of ocular rigidity was 0.0221 (standard deviation 0.0058, range 0.0032~0.0370). There was a statistically significant increase with age. It was higher in males than in females. But there was no statistically significant difference between sex. In myopic eyes. the average coefficient of ocular rigidity was 0.0189. There was an increase with refractive power but it was not statistically significant. In glaucomatous eyes. the average coefficient of ocular rigidity was 0.0181 in the medication-treated group and 0.0163 in the operated group. They were significantly lower than in normal eyes statistically. But there was no significant differance between medication-treated and operated groups.
Female ; Humans ; Intraocular Pressure ; Male ; Nomograms

An accurate system for predicting the survival of patients with oral squamous cell carcinoma (OSCC) will be useful for selecting appropriate therapies. A nomogram for predicting survival was constructed from 96 patients with primary OSCC who underwent surgical resection between January 1994 and June 2003 at the Yonsei Dental Hospital in Seoul, Korea. We performed univariate and multivariate Cox regression to identify survival prognostic factors. For the early stage patients group, the nomogram was able to predict the 5 and 10 year survival from OSCC with a concordance index of 0.72. The total point assigned by the nomogram was a significant factor for predicting survival. This nomogram was able to accurately predict the survival after treatment of an individual patient with OSCC and may have practical utility for deciding adjuvant treatment.
Carcinoma, Squamous Cell ; Humans ; Korea ; Nomograms

PURPOSE: No standard number of cores is obtained with a prostate needle biopsy. Routinely, we obtain 10 core biopsies but do not consider prostate volume or patient age. Consequently, we evaluated the clinical efficacy of prostate biopsy when taking into account prostate volume and patient age by use of the Vienna nomogram to suggest the proper number of cores. MATERIALS AND METHODS: Transrectal ultrasonography (TRUS)-guided prostate needle biopsies were performed in 326 patients between November 2006 and June 2009. Group A (10 cores biopsy) was 131 patients. Group B (biopsy using Vienna nomogram) was 134 patients. We compared the cancer detection rate between the two groups, especially according to age and prostate volume. The chi-squared test was used for statistical analysis. RESULTS: The overall cancer detection rates in groups A and B were 33.6% and 32.1%, respectively. In older patients (age> or =60 years), group B had a higher detection rate than did group A (37.0% vs. 35.6%). For patients with a small prostate (<30 g), group B had a significantly higher detection rate than did group A (62.1% vs. 30.4%, p=0.023). CONCLUSIONS: There was no significant difference in the overall cancer detection rate. However, in patients with a small prostate and in older patients, the Vienna nomogram was more effective than a 10-core biopsy. The Vienna nomogram could help to establish guidelines for prostate biopsy in Korea that take into account the prostate volume and the age of the patient. It could also help urologists to reduce unnecessary cores when diagnosing prostate cancer in the elderly population and in those with small prostates.
Aged ; Biopsy ; Biopsy, Needle ; Humans ; Korea ; Nomograms ; Prostate ; Prostatic Neoplasms

PURPOSE: To determine the uroflow rates of normal Korean pediatric male, uroflowmetry was peformed. MATERIALS AND METHODS: A total of the 237 normal children who ranged in age from 2 to 14 years(mean: 7.2+/-2.1years)was available for this study. Uroflow 1 data(peak and average flow) were plotted in volume-related nomograms in 3 different age groups : 2 to 4, 5 to7 and 8 to 14 years old. RESULTS: The mean peak flow(10.3+/-3.7, 12.2+/-4.9 and 14.3+/-5.2m1/sec) and average flow(6.4+/-2.6, 7.1)3.0 and 8.3+/-3.4m1/sec) were increased significantly with increasing age(p<0.05). In a same voided volume the peak and average flow rates were not increased significantly with increasing age but, in a same age group they were significantly increased according to the volume voided (p<0.05). Peak and average flow rates in the circumcision group(13.7+/-6.7, 8.3+/-4.7m1/sec) was not significantly different from non-circumcision group(10.9+/-5.0, 16.1+/-3.0ml/sec). CONCLUSIONS: These uroflow rate nomograms will be useful for the assessment of voiding action related to the voided volume and age in Korean pediatric males.
Adolescent ; Child ; Circumcision, Male ; Female ; Humans ; Korea* ; Male* ; Nomograms*