1.Mycobacterium kansasii Pulmonary Diseases in Korea.
Jae Joon YIM ; Young Kil PARK ; Woo Jin LEW ; Gill Han BAI ; Sung Koo HAN ; Young Soo SHIM
Journal of Korean Medical Science 2005;20(6):957-960
Mycobacterium kansasii is one of the most common cause of pulmonary diseases due to nontuberculous mycobacteria. We investigated the changing in the number of isolation of M. kansasii and the clinical characteristics of M. kansasii pulmonary disease in Korea. Through searching the database of the Korean Institute of Tuberculosis, we identified the cases of isolated M. kansasii from 1992 to 2002. The number of M. kansasii isolation had increased from once in 1992 to 62 in 2002. Fifteen patients with M. kansasii pulmonary disease were identified during the period January 1997 to December 2002. Twelve patients (80%) were male and fourteen (93%) were from highly industrialized areas. The most common symptom was a cough. Seven patients (47%) had a cavitary lesion and right upper lobe was most commonly involved. Patients responded well to isoniazid and rifampicin based regimens both bacteriologically and radiographically. In conclusion, M. kansasii isolation has increased, especially in highly industrialized areas, as well as other nontuberculous mycobacteria in Korea.
Adult
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Aged
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Anti-Bacterial Agents/therapeutic use
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Female
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Humans
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Korea/epidemiology
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Lung Diseases/diagnosis/drug therapy/*epidemiology/microbiology
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Male
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Middle Aged
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Mycobacterium Infections, Atypical/diagnosis/drug therapy/*epidemiology/microbiology
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*Mycobacterium kansasii/isolation and purification
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Research Support, Non-U.S. Gov't
2.Disseminated Mycobacterium kansasii Infection Associated with Skin Lesions: A Case Report and Comprehensive Review of the Literature.
Sang Hoon HAN ; Kyoung Min KIM ; Bum Sik CHIN ; Suk Hoon CHOI ; Han Sung LEE ; Myung Soo KIM ; Su Jin JEONG ; Hee Kyoung CHOI ; Chang Oh KIM ; Jun Yong CHOI ; Young Goo SONG ; June Myung KIM
Journal of Korean Medical Science 2010;25(2):304-308
Mycobacteruim kansasii occasionally causes disseminated infection with poor outcome in immunocompromised patients. We report the first case of disseminated M. kansasii infection associated with multiple skin lesions in a 48-yr-old male with myelodysplastic syndrome. The patient continuously had taken glucocorticoid during 21 months and had multiple skin lesions developed before 9 months without complete resolution until admission. Skin and mediastinoscopic paratracheal lymph node (LN) biopsies showed necrotizing granuloma with many acid-fast bacilli. M. kansasii was cultured from skin, sputum, and paratracheal LNs. The patient had been treated successfully with isoniazid, rifampin, ethmabutol, and clarithromycin, but died due to small bowel obstruction. Our case emphasizes that chronic skin lesions can lead to severe, disseminated M. kansasii infection in an immunocompromised patient. All available cases of disseminated M. kansasii infection in non HIV-infected patients reported since 1953 are comprehensively reviewed.
Antitubercular Agents/therapeutic use
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Clarithromycin/therapeutic use
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Glucocorticoids/therapeutic use
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Humans
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Immunocompromised Host
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Isoniazid/therapeutic use
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Male
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Middle Aged
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Mycobacterium Infections, Nontuberculous/*diagnosis/drug therapy/immunology
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*Mycobacterium kansasii/isolation & purification
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Myelodysplastic Syndromes/drug therapy
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Rifampin/therapeutic use
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Skin Diseases, Bacterial/*diagnosis/immunology/pathology
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Sputum/microbiology
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Sweet Syndrome/diagnosis