Autoimmune Diseases ; diagnosis ; therapy ; Humans ; Liver Diseases ; diagnosis ; therapy

Humans ; Liver Diseases, Alcoholic ; diagnosis ; etiology ; therapy

Chemical and Drug Induced Liver Injury ; Humans ; Liver Diseases ; diagnosis ; therapy

In the post-genomic era, the focus of research is now moving to functional genomics employing the information on predicted gene products provided by genome sequencing. Proteomics, the global analysis of structures, functions, and interactions of whole cellular proteins, draws the special attention as a tool for documenting the disease pathogenesis or progression. The high-throughput technology has become feasible by considerable improvement of two dimensional electrophoresis and mass fingerprinting. Thus proteome techniques can be used as tools to study the disease processes, develop new biomakers for diagnosis and early detection of diseases, and accelerate drug development. In this review, we discuss the background and techniques of proteomics, and potential applications to the research of gastrointestinal diseases.
English Abstract ; *Gastrointestinal Diseases/diagnosis/therapy ; Humans ; *Liver Diseases/diagnosis/therapy ; *Proteomics

Autoimmune Diseases ; diagnosis ; genetics ; therapy ; Humans ; Liver Diseases ; diagnosis ; genetics ; therapy

Bone Diseases, Metabolic ; diagnosis ; etiology ; therapy ; Chronic Disease ; Humans ; Liver Diseases ; complications ; diagnosis ; therapy

Guidelines as Topic ; Humans ; Liver Diseases, Alcoholic ; diagnosis ; therapy ; United States

In 2015, the Chinese Society of Hepatology and Chinese Society of Gastroenterology issued the consensus on the diagnosis and management of cholestatic liver diseases. In the past years, more data have emerged from clinical practice. Herein, the Autoimmune Liver Disease Group of the Chinese Society of Hepatology organized an expert group to review the evidence and updated the recommendations to formulate the guidelines. There are 22 recommendations on clinical practice of cholestatic liver diseases. The guidelines aim to provide a working reference for the management of cholestatic liver diseases.
Autoimmune Diseases/diagnosis* ; Cholestasis/therapy* ; Consensus ; Gastroenterology ; Humans ; Liver Diseases/therapy*

Carcinoma, Hepatocellular ; diagnosis ; therapy ; Gastroenterology ; trends ; Hepatitis, Viral, Human ; diagnosis ; therapy ; Humans ; Liver Cirrhosis ; diagnosis ; therapy ; Liver Diseases ; diagnosis ; therapy ; Liver Failure, Acute ; etiology ; therapy ; Liver Neoplasms ; diagnosis ; therapy ; Retrospective Studies

Diabetes Mellitus, Type 2 ; complications ; diagnosis ; therapy ; Humans ; Liver Diseases ; complications ; diagnosis ; therapy