1.Benign nodules mimicking hepatocellular carcinoma on gadoxetic acid-enhanced liver MRI.
Kyoung Doo SONG ; Woo Kyoung JEONG
Clinical and Molecular Hepatology 2015;21(2):187-191
No abstract available.
Adenoma, Bile Duct/pathology/*radiography
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Adult
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Aged
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Angiomyolipoma/pathology/*radiography
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Bile Duct Neoplasms/pathology/*radiography
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Bile Ducts, Intrahepatic
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Carcinoma, Hepatocellular/radiography
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Diagnosis, Differential
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Female
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Gadolinium DTPA/*chemistry
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Humans
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Liver Diseases/pathology/*radiography
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Liver Neoplasms/pathology/*radiography
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*Magnetic Resonance Imaging
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Male
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Middle Aged
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Pseudolymphoma/pathology/*radiography
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Tomography, X-Ray Computed
2.Hepatocellular carcinoma composed of two different histologic types: imaging features on gadoxetic acid-enhanced liver MRI.
Seung Hyun KIM ; Woo Kyoung JEONG ; Yongsoo KIM ; Min Yeong KIM ; Jinoo KIM ; Ju Yeon PYO ; Young Ha OH
Clinical and Molecular Hepatology 2013;19(1):92-96
No abstract available.
Antigens, CD34/metabolism
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Carcinoma, Hepatocellular/pathology/*radiography
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Contrast Media/chemistry/diagnostic use
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Gadolinium DTPA/chemistry/*diagnostic use
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Humans
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Immunohistochemistry
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Liver Neoplasms/pathology/*radiography
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Tomography, X-Ray Computed
3.Cholangiocarcinoma with a paraneoplastic leukemoid reaction mimicking a pyogenic liver abscess.
Hyoju HAM ; Hee Yeon KIM ; Kyung Jin SEO ; Su Lim LEE ; Chang Wook KIM
The Korean Journal of Internal Medicine 2015;30(1):110-113
No abstract available.
Bile Duct Neoplasms/complications/*diagnosis
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*Bile Ducts, Intrahepatic/chemistry/pathology/radiography
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Biopsy
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Cholangiocarcinoma/complications/*diagnosis
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Diagnosis, Differential
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Fever/diagnosis/*etiology
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Humans
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Immunohistochemistry
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Leukocytosis/*diagnosis/etiology
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*Liver/chemistry/pathology/radiography
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Liver Abscess, Pyogenic/*diagnosis
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Paraneoplastic Syndromes/*diagnosis/etiology
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Predictive Value of Tests
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Tomography, Spiral Computed
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Tumor Markers, Biological/analysis
4.Dynamic Contrast-Enhanced MRI Using a Macromolecular MR Contrast Agent (P792): Evaluation of Antivascular Drug Effect in a Rabbit VX2 Liver Tumor Model.
Hee Sun PARK ; Joon Koo HAN ; Jeong Min LEE ; Young Il KIM ; Sungmin WOO ; Jung Hwan YOON ; Jin Young CHOI ; Byung Ihn CHOI
Korean Journal of Radiology 2015;16(5):1029-1037
OBJECTIVE: To evaluate the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using macromolecular contrast agent (P792) for assessment of vascular disrupting drug effect in rabbit VX2 liver tumor models. MATERIALS AND METHODS: This study was approved by our Institutional Animal Care and Use Committee. DCE-MRI was performed with 3-T scanner in 13 VX2 liver tumor-bearing rabbits, before, 4 hours after, and 24 hours after administration of vascular disrupting agent (VDA), using gadomelitol (P792, n = 7) or low molecular weight contrast agent (gadoterate meglumine [Gd-DOTA], n = 6). P792 was injected at a of dose 0.05 mmol/kg, while that of Gd-DOTA was 0.2 mmol/kg. DCE-MRI parameters including volume transfer coefficient (K(trans)) and initial area under the gadolinium concentration-time curve until 60 seconds (iAUC) of tumors were compared between the 2 groups at each time point. DCE-MRI parameters were correlated with tumor histopathology. Reproducibility in measurement of DCE-MRI parameters and image quality of source MR were compared between groups. RESULTS: P792 group showed a more prominent decrease in K(trans) and iAUC at 4 hours and 24 hours, as compared to the Gd-DOTA group. Changes in DCE-MRI parameters showed a weak correlation with histologic parameters (necrotic fraction and microvessel density) in both groups. Reproducibility of DCE-MRI parameters and overall image quality was not significantly better in the P792 group, as compared to the Gd-DOTA group. CONCLUSION: Dynamic contrast-enhanced magnetic resonance imaging using a macromolecular contrast agent shows changes of hepatic perfusion more clearly after administration of the VDA. Gadolinium was required at smaller doses than a low molecular contrast agent.
Animals
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Antineoplastic Agents/therapeutic use
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Benzophenones/therapeutic use
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Disease Models, Animal
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Heterocyclic Compounds/administration & dosage/*chemistry
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Liver Neoplasms/drug therapy/pathology/*radiography
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*Magnetic Resonance Imaging
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Male
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Organometallic Compounds/administration & dosage/*chemistry
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Rabbits
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Reproducibility of Results
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Valine/analogs & derivatives/therapeutic use