1.Study on the effects of FCu-IUD and FICu-IUD on matrix metalloproteinases in human uterine flushing and endometrium.
Wei LI ; Lumin CAO ; Zaojao CHEN ; Wan LI ; Qingling DU ; Guiping CHEN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2002;22(1):9-16
The activity of matrix metalloproteinases (MMPs) in the uterine flushing and endometrial tissue of normal adult women wearing FCu-IUD (fixed Cu-IUD) or FICu-IUD (indomethacin-releasing FCu-IUD) was observed by using zymography on SDS-PAGE containing gelatin. The results showed that the activity and kinds of MMPs in FCu-IUD group were increased significantly as compared with themselves before being inserted FCu-IUD. However, compared with the FCu-IUD group, the activity of some kinds of MMPs in the FICu-IUD group was decreased significantly. These data suggest that IUD can enhance the activity of MMPs in human endometrium, intermediated by prostaglandins, and MMPs may have relation to IUD-induced menorrhagia and indomethacin reduces IUD-induced menorrhagia by partly inhibiting MMPs synthesis.
Adult
;
Endometrium
;
enzymology
;
Female
;
Humans
;
Indomethacin
;
Intrauterine Devices, Copper
;
adverse effects
;
Intrauterine Devices, Medicated
;
adverse effects
;
Matrix Metalloproteinases
;
metabolism
;
Middle Aged
;
Uterine Hemorrhage
;
etiology
;
prevention & control
2.Study on the effects of FCu-IUD and FICu-IUD on matrix metalloproteinases in human uterine flushing and endometrium.
Wei, LI ; Lumin, CAO ; Zaojao, CHEN ; Wan, LI ; Qingling, DU ; Guiping, CHEN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2002;22(1):9-11, 16
The activity of matrix metalloproteinases (MMPs) in the uterine flushing and endometrial tissue of normal adult women wearing FCu-IUD (fixed Cu-IUD) or FICu-IUD (indomethacin-releasing FCu-IUD) was observed by using zymography on SDS-PAGE containing gelatin. The results showed that the activity and kinds of MMPs in FCu-IUD group were increased significantly as compared with themselves before being inserted FCu-IUD. However, compared with the FCu-IUD group, the activity of some kinds of MMPs in the FICu-IUD group was decreased significantly. These data suggest that IUD can enhance the activity of MMPs in human endometrium, intermediated by prostaglandins, and MMPs may have relation to IUD-induced menorrhagia and indomethacin reduces IUD-induced menorrhagia by partly inhibiting MMPs synthesis.
Endometrium/*enzymology
;
Indomethacin
;
Intrauterine Devices, Copper/*adverse effects
;
Intrauterine Devices, Medicated/*adverse effects
;
Matrix Metalloproteinases/*metabolism
;
Uterine Hemorrhage/etiology
;
Uterine Hemorrhage/prevention & control
3.Magnetic Field Interactions of Copper-Containing Intrauterine Devices in 3.0-Tesla Magnetic Resonance Imaging: In Vivo Study.
Vanessa BERGER-KULEMANN ; Henrik EINSPIELER ; Nilouparak HACHEMIAN ; Daniela PRAYER ; Siegfried TRATTNIG ; Michael WEBER ; Ahmed BA-SSALAMAH
Korean Journal of Radiology 2013;14(3):416-422
OBJECTIVE: An ex vivo study found a copper-containing intrauterine device (IUD) to be safe for women undergoing an MRI examination at a 3.0-T field. No significant artifacts caused by the metallic implant were detected. However, there are still no in vivo data about these concerns. The aim of this study was to evaluate 3.0-T magnetic field interactions of copper-containing IUDs in vivo. MATERIALS AND METHODS: Magnetic field interactions and potential adverse events were evaluated in 33 women using a questionnaire-based telephone survey. Two experienced radiologists performed artifact evaluation on MR images of the pelvis. RESULTS: Eighteen patients were eligible for the survey. One patient reported a dislocation of the IUD after the MR examination. All other patients had no signs of field interactions. No IUD-related artifacts were found. CONCLUSION: MRI at 3.0-T is possible for women with copper-containing IUDs. However, consulting a gynecologist to check the correct position of the IUD and exclude complications after an MR examination is highly recommended. High-quality clinical imaging of the female pelvis can be performed without a loss in image quality.
Adult
;
Artifacts
;
*Copper
;
Female
;
Hot Temperature
;
Humans
;
*Intrauterine Devices, Copper/adverse effects
;
Magnetic Fields
;
Magnetic Resonance Imaging/adverse effects/*methods
;
Middle Aged
;
Pelvis