2.Assessment of Quality of Life and Associated Factors in Patients with Chronic Viral Liver Disease.
Chang Keun PARK ; Soo Young PARK ; Eun Soo KIM ; Jin Hyung PARK ; Dong Woo HYUN ; Young Mi YUN ; Chang Min JO ; Won Young TAK ; Young Oh KWEON ; Sung Kook KIM ; Yong Hwan CHOI ; Shin Goo PARK
The Korean Journal of Hepatology 2003;9(3):212-221
BACKGROUND/AIMS: The aim of this study was to measure health related quality of life (HRQOL) in patients with chronic viral hepatitis or cirrhosis and to determine factors associated with more severe impairment. METHODS: We conducted a cross-sectional study in which we documented patients' demographic and clinical characteristics and measured their HRQOL using the Korean version of Short Form-36. A total of 375 patients were enrolled in the study. We compared patients' HRQOL with that of 750 participants in a control group and assessed the association of HRQOL impairment with clinical parameters. RESULTS: In all except two domains (physical functioning, bodily pain) of SF-36, HRQOL scores were significantly lower in the patient group than in the control group (p<0.001). The difference was more prominent in those domains reflective of mental, rather than physical, health. When patient group was classified as noncirrhosis, Child A, B, or C according to modified Child-Pugh classification, severe liver disease was associated with a lower HRQOL score. Interestingly, scores of domains reflective of mental health were decreased from the early stage of disease (noncirrhosis or Child-Pugh A). Those of domains reflective of physical health, however, were decreased only in advanced stages of disease (Child-Pugh B or C). There are weak but significant correlations between SF-36 scores and age, serum albumin, serum bilirubin, and prothrombin time, but no correlation with histologic activity, transaminase level, disease duration, virus type (HBV or HCV) and HBV DNA level. CONCLUSIONS: Compared with the control group, patients with chronic viral hepatitis or cirrhosis showed substantial impairment of HRQOL, which is further affected by worsening disease severity. More concern about HRQOL should be warranted in the evaluation of health change due to disease progression or therapeutic trial.
Adult
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Female
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*Hepatitis B, Chronic/physiopathology/psychology
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*Hepatitis C, Chronic/physiopathology/psychology
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Humans
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Liver Cirrhosis/physiopathology/psychology
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Male
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Middle Aged
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*Quality of Life
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Questionnaires
3.Psychometrics of the chronic liver disease questionnaire for patients with posthepatitic B cirrhosis.
Xin-cai HU ; Hua ZHANG ; Yan LIN ; Yang ZHOU ; Ping LIU
Chinese Journal of Hepatology 2012;20(8):621-627
To report on the validity and reliability of the Chronic Liver Disease Questionnaire (CLDQ) for assessing subjects with posthepatitic B cirrhosis. The CLDQ was administered to 117 healthy volunteers and 297 patients with posthepatitic B cirrhosis. All posthepatic B cirrhosis patients were assessed for the Child-Pugh stage. The entire questionnaire and each individual item was analyzed for precision and reliability. Exploratory factor analysis, responsiveness, and discrimination validity were also assessed. No significant floor effects were detected, but a moderate ceiling effect (less than 30%) was found for the following subscales: abdominal symptoms (AS), activity (AC), and worry (WO). For most items, the ceiling effect was between 30% to 60%. The internal consistency (Cronbach's a) on total scale level was good (a = 0.905), and ranged from 0.442 to 0.848 for the different subscales. The correlation coefficients of the total scale with subscales were above 0.6 (P less than 0.01) for reliability. The CLDQ and subscale scores for healthy controls were higher than those for the patients (P less than 0.001), and were gradated from the patients with Child-Pugh A cirrhosis to those with Child-Pugh B or C cirrhosis. Increase in severity of liver disease was accompanied by lower scores by the CLDQ and 4 out 6 subscales. Exploratory factor analysis moderately reproduced the original factor structure. The CLDQ has good reliability, satisfactory content, responsiveness and discriminant validity, and moderate precision and construct validity. It is useful for effectively evaluating health-related quality of life and curative effect in patients with posthepatitic B cirrhosis.
Adolescent
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Adult
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Aged
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Case-Control Studies
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Chronic Disease
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Female
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Health Status
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Hepatitis B, Chronic
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psychology
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Humans
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Liver Cirrhosis
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psychology
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Male
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Middle Aged
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Pain
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physiopathology
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psychology
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Psychometrics
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Quality of Life
;
psychology
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Reproducibility of Results
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Sensitivity and Specificity
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Severity of Illness Index
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Statistics as Topic
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Surveys and Questionnaires
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Young Adult