No abstract available.
Free Radicals* ; Reperfusion*

The continuous mutation of many genes is fundamental changes in the period of cancer occurrence. The gene expression shows itself process of nitrogen base in DNA which plays the role of synthesis of information RNA and transport RNA in the protein synthesis. The 8 oxygen-G generation damages DNA which induces gene mutation in all oxygenation mutation that initiating the process of tumor occurrence. Therefore, the reduction of oxygen free radical will contribute to the reduction of development of tumors, changing from benign tumor to malignant tumor and the occurrence of cancer in clinical.
Free Radicals ; Mutation

The free radicals can be generated in the normal or physiopathological conditions. They play an important role in the mechanism of many diseases. The anti-oxidant agents such as vitamine E, C, beta-caroten and organic seleminum have effects in treatment of some disease, upgrading the life’s quality, anti - aging process, lasting of the human health and useful living duration.
Free Radicals ; Disease

In 1969, Mc Cord and Fridovich discovered an enzyme that had an antioxidative activity – it was superoxide dismatase (SOD). In 1984, Cutler R.G determined the pathogenic roles of free radicals in biology. In 1986, Marman D mentioned the relationship of free radicals and origin and development of organism, relationship with pathogenesis and aging
Free Radicals ; Therapeutics ; Antioxidants

The role of ascorbate as an antioxidant in the prevention and cure of disease that result from free radicals has been of considerable interest and controversy lately. As an antioxidant, we can expect it to protect against radiation damage caused by free radicals that are produced when radiation, especially sparsely ionizing radiation, interacts with living tissues. The plasma and whole blood concentration of ascorbate was analyzed before and just after the radiation therapy for the purpose of estimating the consumption amount of ascorbate during radiotherapy. Whole blood ascorbate was decreased from 1.82 mg/dl to 1.58 mg/dl, plasma ascorbate was decreased from 1.13 mg/dl to 1.08 mg/dl, and urine ascorbate was decreased from 9.33 mg/dl to 6.96 mg/dl after radiotherapy. Although the difference was not significant statistically, further human study should be followed to define the role of ascorbate as a radioprotector.
Free Radicals ; Humans ; Plasma* ; Radiation, Ionizing ; Radiotherapy*

The extract of dried herb of Gynura procubens, ratio 1:1, is used for antioxidative activity. In special, to strongly inhibit the free formation of anion superoxide O2, reaches 49.63% among 160mg/ml. To inhibit the peroxide lipid the same mouse liver's cells: 33.30mg/ml (inhibition 14.78%); and with 166.50mg/ml, the MDA is about 58.90%. There is inhibiting effect for peroxide lipid in the liquid of mice brain's cells
Superoxides ; Free Radicals ; Rats ; Animal Experimentation

Dosimetry based on electron spin resonance(ESR) analysis of radiation induced free radicals in amino acids is relevant to biological dosimetry applications. Alanine detectors are without walls and are tissue equivalent. Therefore, alanine ESR dosimetry looks promising for use in the therapy level. The dose range of the alanine/ESR dosimetry system can be extended down to l Gy. In a water phantom the absorbed dose of electrons generated by a medical linear accelerator of different initial energies (6~21 MeV) and therapeutic dose levels(1~60 Gy) was measured. Furthermore, depth dose measurements carried out with alanine dosimeters were compared with ionization chamber measurements. As the results, the measured absorbed doses for shallow depth of initial electron energies above 15 MeV were higher by 2~ 5% than those calculated by nominal energy CE factors. This seems to be caused by low energy scattered beams generated from the scattering foil and electron cones of beam projecting device in medical linear accelerator.
Alanine ; Amino Acids ; Free Radicals ; Particle Accelerators ; Spectrum Analysis* ; Water

BACKGROUND: Each kind of human cell has its own characteristic morphological and functional property. In the skin, epidermal cells, including keratinocyte and melanocyte, also have their own functional characteristics. Thus, it is expected that there are some different responses to external stimuli, such as ionizing radiatio,, free radicals, and cytokines between these cells. OBJECTIVE AND METHODS: To im estigate whether there are different effects of UV light on the viability of cultured human ker tinocytes and rnelanocytes. Cultured human keratinocytes and melanocytes are irradiated by UVB at 5, 25, 50, and 100mJ/cm, and examined by Methylthiazole tetrazollium assay at 0, 1, 3, 6, 24, 48, and 72 hours after UVB exposure. RESULTS: 1. The effects on viability according to the doses of UVB are as follows: 1) In the keratinocytes, the viability was increased in most of the UVB exposure groups within 24 hours after UVB exposure, and was significantly increased at 25, 50, and 100mJ/cm of UVB at 3 hours after UVB exposur.(p<0.05). However, the viability was significantly decreased at relatively high doses of UVB (50, 100mJ/cm) from 48 hours after UVB exposure (p<0.05). 2) In the melanocytes, the viability was decreased in all of the UVB exposure groups within 3 hours, and was significantly decreased in all of the UVB exposure groups at, 1 hour after UVB exposure (p<0.05). The viability was increased from 6 to 24 hours, which was significantly decreased at 100mJ/cm of UVB from 48 hours after UVB exposure (p<0.05). 2. The effects on viability according to the time after UVB exposure at the same dose of UUB In both cells, the viability was increased as time went by. The slopes of the viability curve gradually decreased according to the increment of UVB doses. CONCLUSION: The viability of keratinocyte was decreased at 50mJ/cm of UVB which melanocyte did not show decrease. Melanocyte was more easily damaged than keratinocyte in relatively earlier time period after UVB exposure. These results suggest that the change of viability in cultured keratinocyte and melanocyte after UVB exposure at the dose of less than 100mJ/cm is related to the time course after UVB exposure as well as to the UVB dose.
Cytokines ; Free Radicals ; Humans* ; Keratinocytes* ; Melanocytes* ; Skin ; Ultraviolet Rays

Epilepsy is a neurological disorder from many molecular and biochemical responses. In the underlying mechanism, free radicals play an important role in seizure initiation and seizure-induced brain damage. Excessive production of oxygen free radicals and other radical species have been implicated in the development of seizures under pathological conditions and linked to seizure-induced neurodegeneration.
Brain ; Epilepsy* ; Free Radicals* ; Nervous System Diseases ; Oxygen* ; Seizures

free radicals and the inflammatory reaction in response to grafting with a particulate dentin and plaster of Paris mixture, resulting in effective bone healing. In this study, the differences within groups at 4 and 8 weeks were not significant (p > 0.05), nor were the differences between the two experimental groups at 4 and 8 weeks. In comparison with the control group, however, both experimental groups showed superior new bone formation. Although the difference between the two experimental groups was not statistically significant, a tendency for superior new bone formation was detected with the combination of particulate dentin, plaster of Paris, and alginate. Furthermore, more fusion of woven bone and bony trabeculae formation occurred in this group, suggesting that oligosaccharides play a role in the formation and maturation of new bone. In conclusion, the treatment of bone defects by grafting with a mixture of particulate dentin and plaster of Paris alone or with alginate significantly improved the formation of new bone, both quantitatively and qualitatively. The oligosaccharide treatment appeared to improve the formation of new bone quantitatively and qualitatively.]]>
Calcium Sulfate ; Dentin ; Free Radicals ; Humans ; Oligosaccharides ; Osteogenesis ; Transplants