4.Identification and Molecular Evolution of Baillus anthracis Based on PEP - PCR Genomic Fingerprinting and Amplified Fragment Length Polymorphism.
Won Yong KIM ; Eun Ku LEE ; Mi Ok SONG ; Ji Yeon NAM ; Chul Min PARK ; Ki Jung KIM ; Sang In CHUNG ; Chul Soon CHOI
Journal of the Korean Society for Microbiology 2000;35(5):349-349
No Abstract Available.
Dermatoglyphics*
;
Evolution, Molecular*
;
Polymerase Chain Reaction*
5.Identification and Molecular Evolution of Baillus anthracis Based on PEP - PCR Genomic Fingerprinting and Amplified Fragment Length Polymorphism.
Won Yong KIM ; Eun Ku LEE ; Mi Ok SONG ; Ji Yeon NAM ; Chul Min PARK ; Ki Jung KIM ; Sang In CHUNG ; Chul Soon CHOI
Journal of the Korean Society for Microbiology 2000;35(5):349-349
No Abstract Available.
Dermatoglyphics*
;
Evolution, Molecular*
;
Polymerase Chain Reaction*
8.Co-evolutionary analysis on strategy for therapy of spreading cancer.
Ke-Fu WU ; Guo-Guang ZHENG ; Xiao-Tong MA ; Xiao-Fan ZHU ; Ye GUO ; Yu-Hua SONG
Journal of Experimental Hematology 2012;20(3):523-526
Evolutionary medicine can give rational explanation for metabolism diseases via ecology and evolutionary theory. Recently, the view of somatic cell macroevolution was used in the study on the genesis and development of tumors, which provided new insight in the research work on tumors. In this article, the well-adopted tumor therapy strategy, "Dancing with Cancer", was analyzed preliminarily from the point of co-evolution game theory, based on the non-classical immunology theory and genome theory. The importance of increasing host fitness by changing host life-style to enhance tolerance was emphasized, which is the basis of the Dancing with Cancer strategy. On the other hand, the spreading tumor cells are not equally malignant and spreading tumors should be treated as other chronic diseases. Finally, basic and clinical research should be strengthened to improve the efficiency of the "Dancing with Cancer" strategy.
Biological Evolution
;
Game Theory
;
Neoplasms
;
therapy
9.Recent advances of continuous in vivo evolution.
Haotian ZHAI ; Qingsheng QI ; Jin HOU
Chinese Journal of Biotechnology 2021;37(2):486-499
Laboratory evolution is an important approach to improve the performance of microorganisms. In the past decades, the methods for laboratory evolution have developed rapidly and applied widely. However, the commonly used evolution strategies for strains or specific proteins cannot achieve continuous mutation, and require multiple rounds of operation, therefore they are considered as a labor intensive process. The development of mutation and screening technologies have facilitated the development of continuous evolution in vivo and greatly improved the efficiency of laboratory evolution. The continuous in vivo evolution achieves in vivo mutation, perfectly combining mutation with screening to evolve a specific phenotype with minimal human intervention. This review summarizes the recent advances of in vivo continuous evolution technologies for either genome-scale mutation or evolution of specific proteins. The principles of these technologies and their applications are introduced. On this basis, the advantages and limitations of these technologies are discussed. We also give a perspective of future development of continuous in vivo evolution.
Directed Molecular Evolution
;
Humans
;
Mutation
;
Phenotype
;
Proteins
Result Analysis
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