No Abstract Available.
Energy Metabolism* ; Humans*

The purpose of this study was to assess the physical activity and energy balance of weekdays and weekend in male high school students. Fifty healthy male high school students participated in this study. Anthropometric data were collected. Physical activity level (PAL) and energy intake for weekdays and weekend were calculated from a physical activity diary and food diary using the 24-hour recall method and interview. The resting metabolic rate (RMR) and estimated energy requirement (EER) were calculated from the prediction equations suggested in 2015 KDRIs. Total energy expenditure (TEE) was calculated by multiplying RMR by PAL. Mean age of subjects was 15.9±0.33 years. The daily pedometer counts were significantly higher in the weekdays (12,837 steps) than in weekend (6,661 steps) (P<0.001). The PAL of the weekdays (1.63±0.17) was significantly higher than that (1.37±0.26) of the weekend (P<0.001). PAL was significantly correlated with pedometer counts on the weekdays (r=0.495) and weekend (r=0.686). The total energy intakes (2,847.2±681.5 kcal) and TEE (3,046.3±437.3 kcal) of weekdays were significantly higher than those of the weekend. The results of this study would be useful to develop nutrition and exercise programs for male high school students on weekdays and weekend, respectively.
Diet Records ; Energy Intake ; Energy Metabolism* ; Humans ; Male* ; Motor Activity*

Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke and cancers. The brain plays a central role in controlling metabolic physiology in that it integrates information from other metabolic organs, sends regulatory projections and orchestrates the whole-body function. Emerging studies suggest that brain dysfunction in sensing various internal cues or processing external cues may have profound effects on metabolic and other physiological functions. This review highlights brain dysfunction linked to genetic mutations, sex, brain inflammation, microbiota, stress as causes for whole-body pathophysiology, arguing brain dysfunction as a root cause for the epidemic of aging and obesity-related disorders. We also speculate key issues that need to be addressed on how to reveal relevant brain dysfunction that underlines the development of these disorders and diseases in order to develop new treatment strategies against these health problems.
Aging ; Brain/metabolism* ; Energy Metabolism ; Humans ; Hypothalamus/metabolism* ; Obesity/metabolism*

OBJECTIVES: The Energy Expenditure Prediction ProgramTM (EEPP) has been considered as a simple and quantitative method to evaluate physical work load. However, the adoption of EEPP directly to Korean workers is problematic because it was developed in a laboratory setting for Caucasians. Therefore, this study was conducted to validate EEPP for Korean workers. METHODS: The study subjects consisted of 60 workers from two factories. Cycle ergometer test was conducted to calculate physical work capacity, and heart rate monitoring was conducted to check heart rate during work. After observing the task, energy expenditure was estimated by EEPP. RESULTS: EEPP underestimated energy expenditure less than EEHR (energy expenditure checked by heart rate) did(p<0.0001). The factors effecting EEHR were EEPP and task type. After dividing the task into regular and irregular tasks, the irregular task had a larger difference between the values from the two methods. We provided task specific regression models between EEHR and EEPP. CONCLUSIONS: Because EEPP underestimated energy expenditure, it needs to be adjusted before use with Korean workers. It is suggested that different adjusting equations are formulated for regular and irregular tasks. Further study to develop a specific energy estimation model appropriate for Koreans is needed to obtain more precise estimation.
Energy Metabolism* ; Health Expenditures ; Heart ; Heart Rate

The maintenance of bone homeostasis is critical for bone health. It is vulnerable to cause bone loss, even severely osteoporosis when the balance between bone formation and absorption is interrupted. Growing evidence has shown that energy metabolism disorders, such as abnormal glucose metabolism, irregular amino acid metabolism, and aberrant lipid metabolism, can damage bone homeostasis, causing or exacerbating bone mass loss and osteoporosis-related fractures. Here, we summarize the studies of energy metabolism in osteoblasts and osteoclasts and provide a better appreciation of how energy metabolism, especially glucose metabolism maintains bone homeostasis. With this knowledge, new avenues will be unraveled to understand and cue bone-related diseases such as osteoporosis.
Bone and Bones ; Energy Metabolism ; Osteoblasts ; Osteoclasts ; Osteogenesis

Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increased de-novo lipid synthesis, extensively occurs in proliferating cancer cells, but the underneath rationale has remained to be elucidated. Based on the concept of the degree of reduction of a compound, we have recently proposed a calculation termed as potential of electron transfer (PET), which is used to characterize the degree of electron redistribution coupled with metabolic transformations. When this calculation is combined with the assumed model of electron balance in a cellular context, the enforced selective reprogramming could be predicted by examining the net changes of the PET values associated with the biochemical pathways in anaerobic metabolism. Some interesting properties of PET in cancer cells were also discussed, and the model was extended to uncover the chemical nature underlying aerobic glycolysis that essentially results from energy requirement and electron balance. Enabling electron transfer could drive metabolic reprogramming in cancer metabolism. Therefore, the concept and model established on electron transfer could guide the treatment strategies of tumors and future studies on cellular metabolism.
Electrons ; Energy Metabolism ; Glucose ; Glycolysis ; Humans ; Neoplasms

No abstract available.
Amputees* ; Energy Metabolism* ; Humans ; Lower Extremity*

Animals ; Bone and Bones ; metabolism ; Energy Metabolism ; physiology ; Humans ; Osteocalcin ; metabolism

According to the analysis and integration on prior research results regarding meridian essence, it is believed that high-energy metabolism is one of the main characteristics of along-meridian specificity. With discussion on the formation mechanism of along-meridians high-energy metabolism as entry point, it is found out that proteins of voltage-gated calcium channel along the meridians are likely to play an essential role of starting and coupling during the along-meridians functional activity. Thus, the hypothesis "proteins coupling in the meridians" is modified to the hypothesis "calcium channels proteins coupling in the meridians", which opens new path to reveal material basis and action mechanism of meridians.
Calcium ; metabolism ; Calcium Channels ; metabolism ; Energy Metabolism ; Humans ; Meridians

After a series of study of early feeding (EF), we consider the evaporative heat loss from the burn wound is not the main mechanism of burn hypermetabolism. EF could resuscitate the intestine, preserve its structural integrity and function, prevent bacterial translocation and release of inflammatory mediators, reduce muscle protein catabolism and hypermetabolism. Our studies concerning the relationship between EF and hypermetabolism have already extended to involve hypothalamus now. At the end of 1960s, the advancement in "Intravenous Hyperalimentation" has epoch-making significance, but it has been found later that energy has been oversupplied by this measure, thus it exacerbated visceral loading and led to disorder of internal environment, and it has been found not beneficial to alleviate hypermetabolism. Whether "hypocaloric nutrition" for post-operative patients of G-I (gastro-intestine) surgery is applicable to severe burn patients remains as a problem. Some specialists suggest it is better to supply 126 approximately 146 kJxkg(-1)x d(-1) in severe burn patients. After evaluating the bias and precision of 46 methods of estimating energy supply of burn patients reported from 1953 to 2000, Dickerson RN et al. concluded that the most precise, unbiased methods were those of Milner (1994), Zawacki (1970) and TMMU (1993, Third Military Medical University formula). Though formulas are simple and convenient to estimate energy supplementation, however, it is difficult to evaluate the requirement of energy when the patient's condition changes immensely.
Burns ; metabolism ; therapy ; Energy Metabolism ; Humans ; Nutritional Support