1.Research on injection flow velocity planning method for embolic agent injection system.
Jiasheng LI ; Dongcheng REN ; Bo ZHOU ; Shijie GUO ; Baolei GUO
Journal of Biomedical Engineering 2022;39(3):579-585
Interventional embolization therapy is widely used for procedures such as targeted tumour therapy, anti-organ hyperactivity and haemostasis. During embolic agent injection, doctors need to work under X-ray irradiation environment. Moreover, embolic agent injection is largely dependent on doctors' experience and feelings, and over-injection of embolic agent can lead to reflux, causing ectopic embolism and serious complications. As an effective way to reduce radiation exposure and improve the success rate of interventional embolization therapy, embolic agent injection robot is highly anticipated, but how to decide the injection flow velocity of embolic agent is a problem that remains to be solved. On the basis of fluid dynamics simulation and experiment, we established an arterial pressure-injection flow velocity boundary curve model that can avoid reflux, which provides a design basis for the control of embolic agent injection system. An in vitro experimental platform for injection system was built and validation experiments were conducted. The results showed that the embolic agent injection flow speed curve designed under the guidance of the critical flow speed curve model of reflux could effectively avoid the embolic agent reflux and shorten the embolic agent injection time. Exceeding the flow speed limit of the model would lead to the risk of embolization of normal blood vessels. This paper confirms the validity of designing the embolic agent injection flow speed based on the critical flow speed curve model of reflux, which can achieve rapid injection of embolic agent while avoiding reflux, and provide a basis for the design of the embolic agent injection robot.
Embolization, Therapeutic/methods*
2.Design and experiment of guide wire tele-manipulation system based on laser mouse sensor.
Jie SHEN ; Shenglin LI ; Daguo CHEN ; Yonghua YAN
Chinese Journal of Medical Instrumentation 2012;36(1):32-35
In order to realize the guide wire tele-manipulation in intervention operation, a method for guide wire motion detection with laser mouse sensor is proposed and experiments are carried out. On that basis, a guide wire tele-manipulation system which consists of guide wire detection appliance, guide wire manipulation appliance, and master slave type software is designed. Experiments are conducted on the system and acquired needed data, so that relationships between operating time and the distance from guide wire tip to destination and the angle are analyzed. The results validate the feasibility of the system and provide good foundation for future research.
Catheterization
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instrumentation
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methods
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Embolization, Therapeutic
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instrumentation
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Equipment Design
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Lasers
3.Hemodynamic effects of stenting on wide-necked intracranial aneurysms.
Yi-sen ZHANG ; Xin-jian YANG ; Sheng-zhang WANG ; Ai-ke QIAO ; Jia-liang CHEN ; Kun-ya ZHANG ; Zhi-cheng LIU ; Yu-jing ZHAO ; Ying ZHANG ; Bin LUO ; Chuan-hui LI
Chinese Medical Journal 2010;123(15):1999-2003
BACKGROUNDStent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.
METHODSThree idealized plexiglass aneurismal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics (CFD) simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD.
RESULTSThe results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac. Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting.
CONCLUSIONSStenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization.
Embolization, Therapeutic ; methods ; Humans ; Hydrodynamics ; Intracranial Aneurysm ; therapy ; Stents
7.Transvenous Coil Embolization for Dural Arteriovenous Fistulas of the Ophthalmic Sheath: Report of Two Cases and Review of the Literature.
Juyoung HWANG ; Kyung Il JO ; Je Young YEON ; Seung Chyul HONG ; Jong Soo KIM
Journal of Cerebrovascular and Endovascular Neurosurgery 2016;18(2):135-140
We present two patients with a dural arteriovenous fistula (dAVF) of the ophthalmic sheath who developed progressive exophthalmos, conjunctival chemosis, and visual loss. These symptoms mimic those of cavernous sinus dAVFs. Dural AVFs of the ophthalmic sheath are extremely rare and their clinical management is controversial. We successfully treated these two patients by transvenous coil embolization. Transvenous embolization appears to be a safe and effective method to treat dAVFs of the ophthalmic sheath.
Cavernous Sinus
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Central Nervous System Vascular Malformations*
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Embolization, Therapeutic*
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Exophthalmos
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Humans
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Methods
8.Transcatheter hyper-selective hepatic arterial embolization for the treatment of polycysitic liver disease.
Feng DUAN ; Mao-qiang WANG ; Feng-yong LIU ; Zhi-jun WANG ; Peng SONG
Chinese Journal of Hepatology 2011;19(1):67-68
Cysts
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therapy
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Embolization, Therapeutic
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methods
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Female
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Hepatic Artery
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Humans
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Liver Diseases
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therapy
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Male
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Middle Aged
10.Transarterial detachable coil embolization combined with ipsilateral intermittent carotid oppression for traumatic carotid-cavernous fistula with small fistula.
Qing HUANG ; Hongbing ZHANG ; Gang WANG ; Jun YANG ; Yanlong HU ; Jianxin LIU
Chinese Journal of Traumatology 2015;18(2):98-101
One case of traumatic carotid-cavernous fistula (TCCF) with small fistula treated by transarterial detachable coil embolization was reported. The intermittent ipsilateral carotid compression was used to identify the final blocking of the residual fistula. The follow-up digital subtraction angiography showed that the TCCF was cured finally. From this case, we conclude that this method may be an effective way to treat TCCF with small fistula.
Adult
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Carotid-Cavernous Sinus Fistula
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therapy
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Embolization, Therapeutic
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methods
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Endovascular Procedures
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Female
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Fistula
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therapy
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Humans