Osteonecrosis is a common disease, mainly affecting femoral head. Good animal models are helpful in research on the pathologic mechanism of osteonecrosis and the exploration of effective treatment. Although it is relatively easy to establish animal models of early osteonecrosis of femoral head using various approaches, it is difficult to develop an animal model that mimics the full range of osteonecrosis of femoral head. In this paper, we reviewed the current researches on experimental animal models of osteonecrosis, with an attempt to provide evidences for choosing the appropriate animal models and find the way of future development.
Animals ; Disease Models, Animal ; Osteonecrosis

Animals ; Disease Models, Animal ; Parkinson Disease ; Zebrafish

Animals ; Arthritis, Rheumatoid ; Disease Models, Animal

Animal models of coronary microcirculation dysfunction are useful in research on the pathology of coronary microcirculation dysfunction and its intervention mechanisms. Currently, such animal modes are prepared mainly by mechanical obstruction and chemical damage form coronary microembolization or microthrombosis. This paper summarizes the currently available preparation techniques and compared their advantages and disadvantages.
Animals ; Coronary Thrombosis ; Disease Models, Animal ; Microcirculation

Animals ; Disease Models, Animal ; Integrative Medicine

Animals ; Disease Models, Animal ; Integrative Medicine

Animals ; Disease Models, Animal ; Hepatitis C ; Mice

Animals ; Disease Models, Animal ; Heart Failure

Animals ; Disease Models, Animal ; Liver Failure

Deep venous thrombosis is a common and serious complication after orthopedics operation, with the characteristics of high incidence rate and death rate, its formation mechanism and the treatment is becoming more and more attention of scholars. Establishment of animal model of deep venous thrombosis can further explore the pathological process of thrombosis or dissolution, is an important means to research of thrombosis mechanism and evaluation of therapeutic method. This review discussed the basic principle of deep venous thrombosis, the selection of experimental animals and making method of animal models.
Animals ; Disease Models, Animal ; Venous Thrombosis ; etiology