PURPOSE: To evaluate the association with corneal thickness and corneal thinnest point using Orbscan topography. METHODS: One hundred and four eyes of the 52 normal subjects who were investigated using an Orbscan topography, were devided into following two groups ; one was inferonasal group which has the thinnest point in inferonasal quadrant(23 eyes, 22.1%), and the other was inferotemporal group which has the thinnest point in inferotemporal quadrant. (79 eyes, 76%) Among them, age-matched 30 eyes were randomly selected. The corneal thickness of two groups were measured at eight meridian of each point distant 1.0, 1.5, 2.0, 2.5, 3.0mm from corneal center. The thickest point and the thinnest point of cornea in two groups were compared and analysed. RESULTS: The thickest point of cornea in two groups was located in the superior portion. The thinnest quadrant was located in the inferonasal portion for inferonasal group and in the inferotemporal portion for inferotemporal group. CONCLUSIONS: The quadrant where the thinnest quadrant existed had the thinnest corneal thickness in comparing with any other quadrant.
Cornea

Degenerations and dystrophies of the cornea may generally be considered in four categories as follows; 1. Senile changes. 2. Degenerations. 3. Dystrqphies. 4. Corneal infiltrations due to metabolic disturbances, (carbohydrate, lipid, protein). In this discussion, many degenerations and dystrophies were reviewed.
Cornea*

In 1978, a nonprogressive corneal dystrophy was seperated from other causes of congenital opacification on the basis of unique clinincal findings and characteristic electronmicroscopic findings. This disorder, termed congenital hereditary stromal dystrophy, appears to the result of disordered stromal fibrogenesis. Recently, the autors have experienced 4 members of a family with typical electronmicroscopic findings of congenital heaeditary stromal dystrophy of the cornea. In this report we describe the characteristic findings of congenital hereditary stromal dystrophy.
Cornea* ; Humans

In order to clarify the initiation and extent of the recovery of sensitivity in the grafted eyes, the corneal sensitivity was measured on 24 normal eyes and 12 grafted eyes with Cochet-Bonnet aesthesiometer. The sensitivity in the central cornea of the normal eyes was 59 +/- 4mm. The grafted eyes showed a significant difference of sensitivity in the different portion of the recipient peripheral cornea. In the corneal graft, some recovery of sensitivity was observed from the first post-operative month and reached 20 +/- 16mm after after 3-month. The sensitivity in the corneal graft was, however, still much lower than the normal eyes and also than the unsevered peripheral cornea. The sensitivity of the corneal graft showed no significant correlation with the age of graft and with the sensitivity of the recipient peripheral cornea.
Cornea ; Transplants*

Chondroitin sulfate (CS) in corneal preservation medium can porolong corneal preservation time. The solutions used in the experimental chambers were made of TC-199 (GIB Co.) either by itself of by adding 1% CS (Sigma) to the TC-199. The evaliation of the viability of corneas can be made by monitoring their physiological parameter. Thus, we monitored the transendothelial electrical potential difference (p.d.) across deepithelialized rabbit corneas. We found that TC-199 containing 1% CS maintained higher p.d.'s than the same solution without CS.
Chondroitin Sulfates* ; Chondroitin* ; Cornea*

PURPOSE: The purpose of this study is to investigate the effect of the suction time in forming the corneal flap with microkeratome on the corneal flap thickness. METHODS: Thirty porcine eyes were randomly assigned into 3 groups according to suction duration: group 1(10 sec), group 2(35 sec) and group 3(60 sec). The Hansatome microkeratome with 160 plate and a suction ring with 8.5mm diameter were used to create corneal flap. The thickness of central cornea was measured with automated ultrasound pachymeter before the procedure. And after making the flap, the remained corneal thickness was measured with the same method. Then, the difference between the two values was thought to be the corneal flap thickness. RESULTS: The mean corneal flap thickness in group1, 2, and 3 were 91.0+/-24.1 micromiter, 110.1+/-8.9 mu m and 127.2+/-6.1 mu m, respectively. The difference was significant among the three groups(p=0.010), and the longer suction duration made the flap thicker. CONCLUSIONS: These results suggest that in forming the corneal flap with microkeratome, the suction duration has an effect on the corneal flap thickness and an increase of suction duration makes the flap thicker in porcine eyes.
Cornea ; Suction* ; Ultrasonography

PURPOSE: To verify the intra-examiner and inter-examiner repeatability of corneal parameters obtained by GALILEI(TM). METHODS: Corneal parameters were measured by GALILEI in 44 eyes of 28 healthy subjects. One examiner took the measurements twice and intra-examiner repeatability was evaluated. Another examiner measured the corneal parameters once again and inter-examiner repeatability was evaluated. RESULTS: Intra-examiner and inter-examiner repeatability were high for corneal parameters including average SimK, flat SimK, steep SimK, average posterior corneal keratometry, flat posterior corneal keratometry, steep posterior corneal keratometry, central corneal thickness, total corneal volume, and average pupil diameter but low for limbus-to-limbus diameter (nasal-temporal and superior-inferior). CONCLUSIONS: Anterior and posterior corneal parameters of GALILEI showed good intra-examiner and inter-examiner repeatability. However, limbus-to-limbus diameter showed poor intra-examiner and inter-examiner repeatability. GALILEI can be useful in clinical applications with special consideration when measuring the limbus-to-limbus diameter.
Cornea ; Eye ; Pupil

62 people (124 eyes) age from 21 to 49 (35 males, 27 females) are divided into 2 groups: in the first group 18 objects (36 eyes) with conjunctivitis, in the second group 44 objects (88 eyes) without conjunctivitis. All objects have taken Shirmer test (I and II), BUT, test of Rose-bengal and fluorescein. All are applied with Sanlein (Santen Agency). And those tests are measured after 1 and 3 months. Results: The Shirmer I and II, and BUT in the group 2 is higher than in the group 1, though BUT of both groups is at under normal level. Test of Rose-bengal 1 and 2 in group 1 is higher than in group 2. The intergrity of epithelial cells is also changed. Tear secretion of both groups at normal physiological level. Sanlein has good effect, partially improves tear indicator
Bodily Secretions ; Cornea ; Computers

In 24 pterygium patients, the corneal curvature was measured before and after surgical removal. The norizontal curvature increased more than 0.5 D in 66.7% of cases on the 2 to 3 weeks postoperatively. The vertical curvature, however, showed no marked tendency to changes, and only 25% of cases showed more than 0.5 D increase on the 2 to 3 weeks postoperatively. As the pterygium invades the cornea extensively, the horizontal corneal curvature increased more markedly.
Cornea ; Humans ; Pterygium*

Granular corneal dystrophy is primary heredofamilial dystrophy of the cornea, which is characterized by the presence of plemorphic milk-white spots in the superficial stroma in the central cornea. This corneal dystrophy was first ,described by Arthur Groenouw in 1890. Since then. many other types of familial corneal dystrophies have been discribed by morphological characteristics. In 1938 BUcklers classified the corneal dystrophy into 3 types; granular, macular and lattice dystrophy, whose nemenclature is now generally accepted. Now we report 2 cases of granular corneal dystrophies which involved 2 sisters in a family.
Cornea ; Humans ; Siblings