In August 2021, three students with diarrhea from the same school visited a local hospital in the S district of Beijing. An epidemic investigation showed that there were more students with diarrhea in the same school and they had one meal together. Campylobacter jejuni was isolated from both patients with diarrhea and asymptomatic food handlers; however, the latter also carried Campylobacter coli. Phylogenomic analysis showed that there was a campylobacteriosis outbreak among the students, and the asymptomatic food handler may have been the source of the infection. Routine inspection and surveillance for Campylobacter is needed for the food producing staff, particularly those cooking in the cafeteria in schools or other public food services.
Humans ; Campylobacter Infections/epidemiology* ; Gastroenteritis ; Diarrhea ; Campylobacter ; Disease Outbreaks

Campylobacter Infections ; Guillain-Barre Syndrome ; microbiology ; Humans

Bacterial Typing Techniques ; Campylobacter Infections ; microbiology ; Campylobacter fetus ; classification ; isolation & purification ; Humans ; Multilocus Sequence Typing

Campylobacter fetus subsp. intestinalis was isolated from the blood of two different patients. One patient was a 46-year-old male with liver cirrhosis and the other a 44-year-old male with co1on carcinoma. These are the second and third documented infections of this kind in Korea. Difficulties of their isolation were well illustrated. For instance, the growth was detected after a long incubation of 4 to 6 days. All of the 3 blood cultures from the carcinoma patient, but on1y 2 of 3 specimens from the other patient, yielded the organism.
Adult ; Campylobacter/isolation & purification* ; Campylobacter Infections/microbiology ; Campylobacter fetus/isolation & purification* ; Colonic Neoplasms/microbiology ; Culture Media ; Human ; Liver Cirrhosis/microbiology ; Male ; Middle Age ; Septicemia/microbiology*

Campylobacter infection causes gastrointestinal symptoms such as abdominal pain or diarrhea. Occasionally, Campylobacter bacteremia affects immunocompromised patients; however, serious outcomes are known to be rare. Here, we present a case of a patient with Campylobacter bacteremia who had underlying liver cirrhosis. The patient had fever and diarrhea. These symptoms subsided after treatment with cefotaxime. Campylobacter jejuni was isolated in the blood culture after 10 days. In addition, previously reported cases of Campylobacter bacteremia in Asian countries were reviewed with respect to antimicrobial sensitivities.
Abdominal Pain ; Asian Continental Ancestry Group ; Bacteremia* ; Campylobacter Infections ; Campylobacter jejuni* ; Campylobacter* ; Cefotaxime ; Diarrhea ; Fever ; Humans ; Immunocompromised Host ; Liver Cirrhosis* ; Liver*

PURPOSE: Timely antibiotic therapy in selected cases of diarrhea associated with bacterial infections can reduce the duration and severity of illness and prevent complications. The availability of a predictive index before identification of causative bacteria would aid in the choice of a therapeutic agent. METHODS: The study included patients admitted to the pediatrics unit at Konyang University Hospital for acute inflammatory diarrhea from August 1, 2015 to July 31, 2016 who underwent multiplex polymerase chain reaction testing. Of 248 patients, 83 had positive results. The clinical symptoms and blood test results were examined in 61 patients with Campylobacter spp. (25 patients), Salmonella spp. (18 patients), and Clostridium perfringens (18 patients) infections. The mean age of the 61 patients (male:femal=31:30) was 84.0±54.8 months, and the mean hospital stay was 4.6±1.7 days. RESULTS: There were no statistical differences in sex, age, clinical symptoms, or signs. Patients with Campylobacter infection were significantly older (P=0.00). C-reactive protein (CRP) levels in patients with Campylobacter infection were higher than those in the other 2 groups, at 9.6±6.1 mg/dL. The results of receiver-operating characteristic curve analysis showed that the cutoff age was ≥103.5 months (sensitivity, 72%; specificity, 86%) and the CRP cutoff level was ≥4.55 mg/dL (sensitivity, 80%; specificity, 69%). CONCLUSION: Age (≥103.5 months) and higher CRP level (≥4.55 mg/dL) were good predictors of Campylobacter enterocolitis. If neither criterion was met, Campylobacter enterocolitis was unlikely (negative predictive value 97.2%). When both criteria were met, Campylobacter enterocolitis was highly likely.
Bacteria ; Bacterial Infections ; C-Reactive Protein ; Campylobacter Infections ; Campylobacter* ; Child* ; Clostridium perfringens ; Diarrhea ; Enteritis* ; Enterocolitis ; Hematologic Tests ; Humans ; Length of Stay ; Multiplex Polymerase Chain Reaction ; Pediatrics ; Salmonella ; Sensitivity and Specificity

Nowadays, industrialization caused a new sort of infectious diseases which had not been noticed before. Most of them can be included into category of food-borne zoonosis, for example, Salmonella, Escherichia coli O157: H7, Campylobacter, Cyclospora cayetanensis, and new variant creutzfeldt-Jakob's disease (nvCJD). Development of diagnostic technology revealed the causative pathogen of many diseases which used to be regarded as non-infectious. The management of opportunistic infections in the increasing population of immunocompromised hosts accompanied with the progress in transplantation became a new challenge to the clinical field.
Campylobacter ; Communicable Diseases ; Communicable Diseases, Emerging* ; Cyclospora ; Escherichia coli O157 ; Immunocompromised Host ; Opportunistic Infections ; Salmonella

BACKGROUND/AIMS: Campylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens that cause PI-IBS. We used a rat model of PI-IBS to investigate the role of CDT in long-term altered stool form and bowel phenotypes. METHODS: Adult Sprague-Dawley rats were gavaged with wildtype C. jejuni (C+), a C. jejuni cdtB knockout (CDT-) or saline vehicle (controls). Four months after gavage, stool from 3 consecutive days was assessed for stool form and percent wet weight. Rectal tissue was analyzed for intraepithelial lymphocytes, and small intestinal tissue was stained with anti-c-kit for deep muscular plexus interstitial cells of Cajal (DMP-ICC). RESULTS: All 3 groups showed similar colonization and clearance parameters. Average 3-day stool dry weights were similar in all 3 groups, but day-to-day variability in stool form and stool dry weight were significantly different in the C+ group vs both controls (P < 0.01) and the CDT- roup (P < 0.01), but were not different in the CDT- vs controls. Similarly, rectal lymphocytes were significantly higher after C. jejuni (C+) infection vs both controls (P < 0.01) and CDT-exposed rats (P < 0.05). The counts in the latter 2 groups were not significantly different. Finally, c-kit staining revealed that DMP-ICC were reduced only in rats exposed to wildtype C. jejuni. CONCLUSIONS: In this rat model of PI-IBS, CDT appears to play a role in the development of chronic altered bowel patterns, mild chronic rectal inflammation and reduction in DMP-ICC.
Adult ; Animals ; Bacterial Toxins ; Campylobacter Infections ; Campylobacter jejuni ; Colon ; Gastroenteritis ; Humans ; Inflammation ; Interstitial Cells of Cajal ; Irritable Bowel Syndrome ; Lymphocytes ; Models, Animal ; Phenotype ; Rats ; Rats, Sprague-Dawley ; Weights and Measures

Septic arthritis of the hip caused by Campylobacter fetus subsp. fetusis very rare. The authoris isolated C. fetus subsp. fetus from a specimen of the left hip. The patient was a 53-year old man with a history of heavy drinking, diabetes, and chronic hepatitis, and had been suffering from avascular necrosis of both femoral heads. It was considered that the organism invaded already damaged tissue of the joint. The patient was treated with intravenous antibiotics and later received successful total hip replacement.
Arthritis, Infectious/*etiology ; *Campylobacter Infections ; Campylobacter fetus/*isolation & purification ; Case Report ; Femur Head Necrosis/etiology ; Hip/*microbiology ; Human ; Male ; Middle Age

OBJECTIVETo understand the occurrence and distribution of Campylobacter jejuni in chicken in China, assess its health risk to the Chinese population, and provide recommendations for effective risk control.

METHODSData from the National Food Safety Risk Surveillance Network on Campylobacter jejuni between 2007 and 2010 and from published articles were analyzed. Eleven parameters were used based on the whole chicken preparation process and prevalence of Campylobacter jejuni for risk assessment by using the Ross-Sumner Method.

RESULTSThe detection rates of Campylobacter jejuni in raw chicken were between 0.29% and 2.28% during 2007-2010 in China (more than 20 provinces). The probability of illness caused by Campylobacter jejuni due to chicken consumption was around six out of one million consumers per day in urban areas and around one out of one million consumers per day in rural areas. Total predicted illnesses per year was about 736 000, accounting for 1.6‰ of the general population in urban areas and about 301 000, accounting for 0.37‰ of the total population in rural areas. The risk rankings of Campylobacter jejuni in chicken were 52 and 49 in urban and rural areas, respectively.

CONCLUSIONA high risk score for Campylobacter jejuni in chicken was obtained in China. This result may contribute to development of food safety management strategies. Key efforts should be made to control the risk of Campylobacter jejuni in chicken in China, especially in chick breeding and chicken preparation processes.

Animals ; Campylobacter Infections ; epidemiology ; veterinary ; Campylobacter jejuni ; Chickens ; China ; epidemiology ; Diet ; Food Handling ; Food Microbiology ; Poultry Diseases ; epidemiology ; Prevalence ; Risk Assessment ; Transportation