Biopsy ; methods ; Humans

The ultrasound is also helpful to make the diagnosis of a variety of soft tissue tumors bacause of its safety, low cost, non-invasiveness and usefulness. We analysed ultrasonographic findings of 43 cases of soft tissue tumors which were histopathologically confirmed by biopsy and obtained the following results. The ultrasonography could effectively image not only the presence, size and location of the lesion, but also the relationship between the lesion and the adjacent structures. And this method could easily identify the consistency of the lesion, solid or cystic nature, be used to guide the percutaneous biopsy and aspiration without exposure to radiation, and afford the differentiation of malignant lesion from benign one. It could also define the eritities of soft tissue tumors by the nature of internal echo, margin of the lesion, internal echo homogeniety, post-acoustic enhancement, and so on.
Biopsy ; Diagnosis ; Methods ; Ultrasonography

Ultrasound (US)-guided breast biopsy has become the main method for diagnosing breast pathology, and it has a high diagnostic accuracy, approaching that of open surgical biopsy. However, methods for confirming adequate lesion retrieval after US-guided biopsy are relatively limited and false-negative results are unavoidable. Determining imaging-pathology concordance after US-guided biopsy is essential for validating the biopsy result and providing appropriate management. In this review article, we briefly present the results of US-guided breast biopsy; describe general aspects to consider when establishing imaging-pathology concordance; and review the various categories of imaging-pathology correlations and corresponding management strategies.
Biopsy* ; Breast* ; Methods ; Pathology ; Ultrasonography

Until now, biopsy methods for subepithelial tumors (SETs) have focused on endoscopic ultrasound (EUS)-guided biopsy; however, these methods have several limitations. We devised a simple method for pathologic diagnosis of SETs. SETs are occasionally diagnosed during endoscopy, and lesions are generally small and asymptomatic. It can be challenging to decide on a management plan for large asymptomatic SETs. EUS imaging provides information regarding the size, layer, and echo pattern of the lesions. Patient management plans have traditionally been determined based on EUS images, whereby the endoscopist chooses to either monitor or remove the tumor. However, EUS alone cannot diagnose and evaluate upper gastrointestinal SETs with high accuracy. As sufficient tissue samples are required for the accurate diagnosis of SETs, EUS-guided biopsy techniques such as EUS fine-needle aspiration and trucut biopsy are currently used. However, these methods have a relatively low diagnostic accuracy and do not always provide information upon immunohistochemical staining. Endoscopists can easily detect a submucosal mass after creating an iatrogenic mucosal ulcer, after which tissue sampling is performed by using endoscopic biopsy. Furthermore, pathologic results can differentiate between benign and premalignant lesions. Here, we introduce a simple method for the pathologic diagnosis of SETs.
Biopsy* ; Biopsy, Fine-Needle ; Diagnosis* ; Endoscopy* ; Humans ; Methods ; Ulcer ; Ultrasonography

The utility of computed axial tomography(CAT) in the diagnosis of spinal disorders has been the subject of considerable interest since the introduction of CAT scanning. Computed tomographic guided needle biopsy of 12 consecutive patients with a variety of undermined spinal disorders resulted in a 100% yield of positive tissue diagnoses, without signlficant complications. The principal advantage of cat guidance is the continuous direct observation of the needle tip position in relation to the target volume. We think that the application of computed tomographic guided needle biopsy in the lesions of the spine is of great value, because it is the single most accurate method of obtaining diagnosis other than by open surgical biopsy.
Animals ; Biopsy ; Biopsy, Needle ; Cats ; Diagnosis ; Humans ; Methods ; Needles ; Spine

BACKGROUNDEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an effective technique used to precisely detect enlarged mediastinal lymph nodes. The efficacy of EBUS-TBNA versus standard modalities for the diagnosis of sarcoidosis remains to be elucidated. In this meta-analysis, we compared the efficacies of these methods.

METHODSWe searched PubMed, Embase, The Cochrane Library, Wanfang, Cpvip, CNKI, and the bibliographies of the relevant references. We analyzed the data obtained with Revman 5.2 (Nordic Cochrane Center, Copenhagen, Denmark) and Stata 12.0 software (Stata Corporation, College Station, TX, USA). The Mantel-Haenszel method was used to calculate the pooled odds ratio (OR) and 95% confidence intervals (CIs).

RESULTSSixteen studies with a total of 1823 participants met the inclusion criteria, and data were extracted regarding the diagnostic yield of each approach. The ORs for EBUS-TBNA versus transbronchial lung biopsy (TBLB) for the diagnosis of sarcoidosis ranged from 0.26 to 126.58, and the pooled OR was 5.89 (95% CI, 2.20-15.79, P = 0.0004). These findings indicated that EBUS-TBNA provided a much higher diagnostic yield than TBLB. The pooled OR for EBUS-TBNA + TBLB + endobronchial biopsy (EBB) versus TBNA + TBLB + EBB was 1.54 (95% CI, 0.61-3.93, P = 0.36), implying that there was no significant difference between their diagnostic yields. However, clinical heterogeneity was reflected in the nature of the studies and in the operative variables.

CONCLUSIONSThe results of this meta-analysis suggest that EBUS-TBNA + TBLB + EBB could be used for the diagnosis of sarcoidosis, if available. At medical centers without EBUS-TBNA, TBNA + TBLB + EBB could be used instead.

Biopsy, Fine-Needle ; methods ; Bronchoscopy ; methods ; Endosonography ; methods ; Female ; Humans ; Image-Guided Biopsy ; methods ; Male ; Sarcoidosis, Pulmonary ; diagnosis ; Ultrasonography ; methods

Biopsy ; Humans ; Kidney ; pathology ; Staining and Labeling ; methods

OBJECTIVETo review hot issues and future direction of renal tumor biopsy (RTB) technique.

DATA SOURCESThe literature concerning or including RTB technique in English was collected from PubMed published from 1990 to 2015.

STUDY SELECTIONWe included all the relevant articles on RTB technique in English, with no limitation of study design.

RESULTSComputed tomography and ultrasound were usually used for guiding RTB with respective advantages. Core biopsy is more preferred over fine needle aspiration because of superior accuracy. A minimum of two good-quality cores for a single renal tumor is generally accepted. The use of coaxial guide is recommended. For biopsy location, sampling different regions including central and peripheral biopsies are recommended.

CONCLUSIONIn spite of some limitations, RTB technique is relatively mature to help optimize the treatment of renal tumors.

Animals ; Biopsy ; methods ; Humans ; Kidney Neoplasms ; diagnosis

Authors measured the bone marrow pressure(B.M.P.) of 59 femoral heads in cases of either suspicious or diagnosed osteonecrosis and obtained the significant relationship between increased B.M.P. and the osteonecrosis. Increased bone marrow pressure provided both predictive and early diagnostic importance in even the preclinical stage of evolution of the disease, which subsequently had core biopsy proved osteonecrosis of femoral head. The results obstained were as follows; 1. Roentgenographically apperent osteonecrosis showed abnormal B.M.P. pattern, which were proved by the core biopsy. 2. In 21 cases of preclinical osteonecrosis, which did not show roentgenographic changes of osteonecrosis, measured B.M.P. parterns indicated as early stage of osteonecrosis in core biopsy at all. 3. The incidence of abnormal pressure pattern I was 51% and that of pattern II was 30%. 4. Enneking radiological staging did not correlate with the results of B.M.P. 5. The measurement of B.M.P. is relatively easy and simple method without any remarkable risk. The results of this study had great meaning in emphasizing the contribution of the bone marrow pressure measurement dianosing the preclinical stage of osteonecrosis, which had no roentgenographical changes and diagnostic symptoms.
Biopsy ; Bone Marrow ; Head ; Incidence ; Methods ; Osteonecrosis

Biopsy ; Brain ; pathology ; Frozen Sections ; methods ; Humans