No abstract available.
Animals ; Autoimmunity* ; Mice*

The immune status in 26 typhoid fever patients has been studied. They are 15 males, 112 females from 16 to 30 years old. This study reveals that: during the fever period of the disease, pronounced disturbances in immune, homeostasis are observed, which are manifested by lymphopenia, with a considerable rise of natural killer (NK) and active rosette forming cells (Ea). At the period of convalescence, the parameters decreased to normal value, except a mild increase of immunoglobulin (IgM, IgG)
Typhoid Fever ; Autoimmunity

No abstract available.
Autoimmunity* ; Hypothyroidism* ; Thyroid Gland*

40 out of 50 subjects bitten by dog/cat were injected completely 4- 6 doses of rabies vaccine. Using ELISA, the authors found that 42.5% of serum samples that taken after injecting 4 doses of rabies vaccine had antibody titer 0.5IU/ml, met the WHO’s minimum requirement. The GMT was 2.71IU/ml. 62.5% of serum samples taken after injecting 6 doses of rabies vaccine had antibody titer 0.5IU/ml. The GMT was 3.14EU/ml
Immune System ; Vaccines ; Rabies ; Autoimmunity

40 out of 50 subjects bitten by dog/cat were injected completely 4- 6 doses of rabies vaccine. Using ELISA, the authors found that 42.5% of serum samples that taken after injecting 4 doses of rabies vaccine had antibody titer ³0.5IU/ml, met the WHO’s minimum requirement. The GMT was 2.71IU/ml. 62.5% of serum samples taken after injecting 6 doses of rabies vaccine had antibody titer ³0.5IU/ml. The GMT was 3.14EU/ml.
Immune System ; Vaccines ; Rabies ; Autoimmunity

Neutrophils are the most abundant white blood cells in the peripheral blood and have long been recognized as the major phagocytes in acute infection by destroying extracellular pathogens. Although research on neutrophils hampered by intractability in the experiments, the newly discovered effector functions of neutrophils includes granular proteins, and cytokines, extracellular traps. With all effector mechanism neutrophils play a critical role in the pathogenesis of acute and chronic infection, autoimmunity and cancer.
Autoimmunity ; Cytokines ; Inflammation ; Leukocytes ; Neutrophils ; Phagocytes ; Proteins

Myasthenia gravis is relatively rare disease which is related autoimmune response. There are various methods of management for myasthenia gravis, but nowaday radical thymectomy is the treatment of choice in the aspect of bringing out complete remission and clinical improvement. Sixteen patient of myasthenia gravis underwent radical thymectomy during last eight years, and its result was analyed. Complete remission was achieved in five patients(31 %) and pharmacological or symptomatic improvement in seven patients(44 %), thus giving a total remission in 12 patients(75 %). Postoperative result was not correlated with age, sex, degree of preoperative symptom, surgical approach, pathologic diagnosis.
Autoimmunity ; Diagnosis ; Humans ; Myasthenia Gravis* ; Rare Diseases ; Thymectomy

PURPOSE: The etiology of chronic nonbacterial prostatitis is unclear but it appears to be either an infectious disease caused by yet unidentified pathogens or a noninfectious form of inflammation. But, recent data showed that the chronic nonbacterial prostatitis is developed from abnormalities in autoimmunity. We examined the serum CD4, CD8, CD4/CD8 and CD16 levels in patients with chronic nonbacterial prostatitis and normal volunteers, so we tried to reveal their differences in both two groups and the relationship of its pathogenesis. MATERIALS AND METHODS: Between Aug. 1996 and Nov. 1996, we examined the serum level of CD4, CD8 and CD16 in patient with chronic nonbacterial prostatitis(n=20) and in normal patients including volunteers(n=16). RESULTS: The results showed decreased CD4, and increased CD8 which lead to decreased CD4/CD8 ratio and normal CD16 levels. CONCLUSIONS: We believe that our experimental data would show changes of T-cell subclones in chronic nonbacterial prostatitis patients and suggest the basic data in understanding the etiology of chronic nonbacterial prostatitis.
Autoimmunity ; Communicable Diseases ; Healthy Volunteers ; Humans ; Inflammation ; Prostatitis* ; T-Lymphocytes*

BACKGROUND: Atopic dermatitis has been thought be a T cell mediated disease and autoimmune response may be responsible for chronicity of typical skin manifestation. Mycophenolate mofetil(MMF), a new immunosuppressive agent can be tried in the treatment of atopic dermatits. OBJECTIVE: We examined the efficacy and safety of MMF in the treatment of atopic dermatitis in Korean patients. METHODS: 7 patients with moderate to severe atopic dermatits were recruited in the treatment of oral MMF 2 g daily for 6 weeks and followed up for another 6 weeks. Severity of atopic dermatitis was measured using SCORAD index. Laboratory examination was performed to check the side effect of MMF during the study. RESULTS: Six of 7 patients finished the treatment courses. After 6 weeks of therapy with MMF, patients' symptoms were improved and mean SCORAD index was significantly reduced from 67.2+/-15.5 to 28.7+/-13.5(p<0.01). Significant side effects such as neutropenia, infection, renal toxicity and hepatotoxicity were not observed. During the follow-up period, patients could be managed by topical steroid and oral antihistamine and flare-up was not observed. CONCLUSION: According to our study, MMF is an effective, safe and well-tolerated immunosuppressive agent in the treatment of moderate to severe atopic dermatitis. MMF is a promising alternative in the treatment of severe atopic dermatitis.
Autoimmunity ; Dermatitis, Atopic* ; Follow-Up Studies ; Humans ; Neutropenia ; Skin Manifestations

Both vitiligo and psoriasis are common skin disorders, which rarely coexist. We report a case of psoriasis which developed on a vitiligo lesion in a 58-year-old woman. We also discuss the possible mechanism of co-localization of vitiligo and psoriasis, including the role of autoimmunity, Koebner phenomenon, and common neuropeptides.
Autoimmunity ; Female ; Humans ; Middle Aged ; Neuropeptides ; Psoriasis* ; Skin ; Vitiligo*