1.Preliminary application of scripting in RayStation TPS system.
Jianying ZHANG ; Jing SUN ; Yun WANG
Chinese Journal of Medical Instrumentation 2013;37(4):297-310
OBJECTIVEDiscussing the basic application of scripting in RayStation TPS system.
METHODSOn the RayStation 3.0 Platform, the programming methods and the points should be considered during basic scripting application were explored with the help of utility scripts. The typical planning problems in the field of beam arrangement and plan outputting were used as examples by ironprthon language.
RESULTSThe necessary properties and the functions of patient object for script writing can be extracted from RayStation system. With the help of NET controls, planning functions such as the interactive parameter input, treatment planning control and the extract of the plan have been realized by scripts.
CONCLUSIONWith the help of demo scripts, scripts can be developed in RayStation, as well as the system performance can be upgraded.
Antineoplastic Protocols ; Radiotherapy Planning, Computer-Assisted ; methods
2.Progress of research on clarithromycin for treatment of multiple myeloma.
Journal of Experimental Hematology 2015;23(1):246-249
Clarithromycin is a 14-membered ring macrolide antibiotics that is widely used in the treatment of infectious disease. Several clinical investigations showed that clarithromycin was highly efficient for multiple myeloma in improving response rate and survival when used in combination with the conventional chemotherapy since 1997. This finding highlights the importance of clarithromycin on the treatment of multiple myeloma. It offers a new regimen for the relapsed/refractory multiple myeloma patients, and provids a new thought for the treatment of multiple myeloma. However, its related mechanism is still unclear, and more investigations are needed. This review summerizes the recent research progress of clarithromycin for treatment of multiple myeloma and its potential mechanisms.
Antineoplastic Combined Chemotherapy Protocols
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Clarithromycin
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Humans
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Multiple Myeloma
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Thalidomide
3.Clinical Research Progress on Transformed Lymphoma -Review.
Bing-Jie WANG ; Xi-Nan CEN ; Han-Yun REN
Journal of Experimental Hematology 2016;24(4):1232-1236
Histologic transformation (HT) is a frequent event in the clinical course of patients with indolent lymphoma with dismal outcome. The diagnosis of HT is based on clinical manifestation, PET-CT and pathologic biopsy, and the latter is a golden standard for HT. There are contradictory data about the impact of initial management on the risk of transformation. Patients who present with HT did not receive R-CHOP or chemotherapy-naive, should receive this regimen. For the subset of patients received R-CHOP prior to HT, the second line chemotherapy for DLBCL should be adopted. Consolidation with HDT-ASCT should be considered for the suitable young patients. The radio-immunotherapy and novel drugs showed a bright perspective for the patients with HT.
Antineoplastic Combined Chemotherapy Protocols
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Humans
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Lymphoma, Non-Hodgkin
4.Retrospective study of the efficacy and safety of treatment with PDD vs PAD in de novo patients with multiple myiloma.
Ling MA ; Chengcheng FU ; Hui LIU ; Song JIN ; Bin GU ; Shuang YAN ; Panfeng WANG ; Yun XU ; Shengli XUE ; Weiyang LI ; Aining SUN ; Depei WU
Chinese Journal of Hematology 2015;36(4):340-343
7.Development of an Eye Care Protocol for ICU Patients.
Ji Soo YOO ; Won Hee LEE ; So Sun KIM ; Il sun KO ; Eui Geum OH ; Sang Hui CHU ; Ju Hee LEE ; Se Won KANG ; Eun Kyeung SONG ; Soo Jung CHANG ; Bok Hee KIM ; Jung Eun LEE
Journal of Korean Academy of Fundamental Nursing 2008;15(1):34-44
PURPOSE: The purpose of this study was to develop an eye care protocol for intensive care unit (ICU) patients. METHOD: A systematic review was conducted to develop an eye care protocol for ICU patients. Searches were performed using computerized databases (CINAHL, MEDLINE, EBM Review) and citation search from 1996 to January 2007. For the keywords, "eye care", and "randomized controlled trial" were used to identify experimental studies regarding eye care for ICU patients. After reviewing the collected studies, a preliminary eye care protocol algorithm was created. Then, content validity was examined with ophthalmologists and ICU nurses. RESULTS: Six studies were included to serve as a basis for framing of the preliminary algorithm. The final eye care protocol was completed after verifying the preliminary algorithm's content validity. The final eye care protocol was organized in the following manner: 3 items in the assessment stage, 7 items in the no-risk stage, 4 items in the low-risk stage, and 5 items in the high-risk stage. CONCLUSION: The results indicate that, for ICU patients, nurses can broaden their knowledge regarding ocular diseases, as well as improve their practice-based eye care nursing performance.
Antineoplastic Combined Chemotherapy Protocols
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Clinical Protocols
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Cytarabine
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Etoposide
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Eye
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Humans
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Intensive Care Units
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Methotrexate
8.Efficacy of continuous low-dose cyclophosphamide and prednisone regimen in refractory multiple myeloma patients with severe heart failure.
Fan ZHOU ; Wei WEI ; Chenhui LING ; Lieping GUO ; Haotian SHI ; Lu LI ; Xiaoling CHEN ; Jian HOU
Chinese Journal of Hematology 2015;36(3):186-190
OBJECTIVETo observe treatment response, survival, safety and the improvement of ECOG in patients with refractory multiple myeloma (MM) with serious heart failure after the administration of continuous low-dose of cyclophosphamide combined with prednisone (CP).
METHODSFrom January 2005 to September 2013, a total of 75 patients were treated by metronomic chemotherapy with continuous low-dose cyclophosphamide (50 mg/d) and prednisone (15 mg/d).
RESULTSAmong the 75 patients, 2 were lost for follow-up. In the 73 available patients, the overall response was 64.4%, including 2 patients (2.7%) with complete remission (CR), 4 cases (5.5%) very good partial remission (VGPR), and 24 patients (32.9%) partial remission (PR). The median survival was 12 months (1-70 months) with a median onset time of 90 days (16-120) and a median progressive freedom survival of 12 months (1-60). The level of B-type natriuretic peptide in responders declined significantly, as compared to no responders [(336.6 ± 30.3) ng/L vs (906.4 ± 104.8) ng/L, P<0.01]. Common adverse events were as follows: 32 (43.8%) cases of bone marrow suppression, 26 (35.6%) cases of infection, 8 cases of dizzy as well as sleepiness (11.0%), 7(9.6%) cases of Cushing syndrome, 4 (5.5%) cases of secondary diabetes mellitus, and 3 (4.1%) cases of edema respectively.
CONCLUSIONThe metronomic chemotherapy of cyclophosphamide combined with prednisone had satisfactory impact on the treatment outcome, including the improvement of cardiac functions and physical capacities, better survival and safety in refractory MM with serious heart failure. It provides a novel regimen for such patients.
Antineoplastic Combined Chemotherapy Protocols ; Clinical Protocols ; Cyclophosphamide ; Heart Failure ; Humans ; Multiple Myeloma ; Prednisone ; Remission Induction ; Treatment Outcome
9.3-Dimensional Dosimetry of Small Field Photon Beam.
Korean Journal of Medical Physics 2012;23(1):54-61
A polymer gel dosimeter was fabricated. A 3-dimensional dosimetry experiment was performed in the small field of the photon of the cyberknife. The dosimeter was installed in a head and neck phantom. It was manufactured from the acrylic and it was used in dosimetry. By using the head and neck CT protocol of the CyberKnife system, CT images of the head and neck phantom were obtained and delivered to the treatment planning system. The irradiation to the dosimeter in the treatment planning was performed, and then, the image was obtained by using 3.0T magnetic resonance imaging (MRI) after 24 hours. The dose distribution of the phantom was analyzed by using MATLAB. The results of this measurement were compared to the results of calculation in the treatment planning. In the isodose curve on the axial direction, the dose distribution coincided with the high dose area, 0.76mm difference on 80%, rather than the low dose area, 1.29 mm difference on 40%. In this research, the fact that the polymer gel dosimeter and MRI can be applied for analyzing a small field in a 3 dimensional dosimetry was confirmed. Moreover, the feasibility of using these for the therapeutic radiation quality control was also confirmed.
Antineoplastic Combined Chemotherapy Protocols
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Cytarabine
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Head
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Magnetic Resonance Imaging
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Neck
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Polymers
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Quality Control
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Thioguanine
10.FOLFOX-4 Combination Chemotherapy as a First-line Treatment in Patients with Advanced Gastric Cancer.
Korean Journal of Medicine 2012;82(1):35-36
The FOLFOX-4 regimen as first-line treatment in patients with advanced gastric cancer has not evidence of category 1 for prolongation of survival in patients with advanced gastric cancer. Therefore, the use is preferred in the second line. But, especially in elderly patients, FOLFOX regimen was active and well tolerated with lower toxicities. Further phase III study is warranted to evaluate the evidence for prolongation of survival in elderly patients or combination therapy with target agents in advanced gastric cancer.
Aged
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Antineoplastic Combined Chemotherapy Protocols
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Drug Therapy, Combination
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Fluorouracil
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Humans
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Leucovorin
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Organoplatinum Compounds
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Stomach Neoplasms