Volume: 49 Issue: 1

1. Advances in research of protein tyrosine phosphatase 1B and its inhibitors Page:1—9
2. Research advances of multi-targeted flavonoids in the intervention of Alzhei-mer's disease Page:10—19
3. Advances in the targeted therapy of tumor-associated fibroblasts Page:20—25
4. Research progress of P-glycoprotein induction Page:26—33
5. Design,synthesis and biological evaluation of phenylsulfonamide-based IDO1 inhibitors Page:34—38
6. Synthesis and bioactivity of mixed phosphonate derivatives of adefovir with hepatic targeting property Page:39—47
7. Design,synthesis and anti-NSCLC activity of hybrids of anilinopyrimidines and diazeniumdiolates Page:48—55
8. Synthesis and cytotoxicity study of cembrane triazole derivatives Page:56—63
9. Synthesis and antitumor activities of 4-(N-aryl)amino-6-long chain alkoxy pteridine derivatives Page:64—71
10. Effect of licorice flavonoids as CDK1 inhibitors against liver cancer in vitro and in vivo Page:72—78
11. Application of rhodamine-based fluorescent molecular probes in visualization of cellular pyruvic acid Page:79—86
12. Detection of copper ions and glutathione based on off-on fluorescent gra-phene quantum dots Page:87—92
13. Determination of 6 residual solvents in selexipag by headspace gas chroma-tography Page:93—96
14. Effects and mechanism ofandrographolide on diabetic nephropathy mice Page:97—101
15. Effects of immunogenic HER2 on the differentiation of T-cell in mouse Page:102—108
16. Preparative optimization and antitumor activity of selenylaed polysaccharides from the extract residue of Sarcandra glabra(Thunb.)Nakai Page:109—116
17. Antitumor efficacy of bispecific antibody mAb04-MICA to human leukemia cell K562 in vitro and in vivo Page:117—124