A Case of Vitiligo Developed on the Sites of DNCB Application in a Patient with Alopecia Areata.
- Author:
Sung Sik KIM
1
;
Young Ju SEO
;
Kwang Ho KIM
;
Kwang Joong KIM
Author Information
1. Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea. true2yourheart@hanmail.net
- Publication Type:Case Report
- Keywords:
DNCB;
Vitiligo
- MeSH:
Alopecia Areata*;
Alopecia*;
Dermatitis, Contact;
Dinitrochlorobenzene*;
Epidermis;
Female;
Humans;
Melanins;
Melanocytes;
Middle Aged;
Pigmentation;
Vitiligo*
- From:Korean Journal of Dermatology
2004;42(4):452-455
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of vitiligo developed on the sites of DNCB application for the treatment of alopecia areata in a 53-year-old woman. Histopathologic studies of the depigmented patches showed absence of melanin pigmentation at the basal layer of the epidermis and a negative reaction for the Fontana-Masson stain. The current theories explaining vitiligo development after topical sensitizer application are that topical sensitizers induce the vitiligo by a direct cytotoxic effect on the melanocytes, or by unmasking latent vitiligo as a result of the Koebner phenomenon due to contact dermatitis, but the exact mechanism is still unclear.
