Primary Intracranial Ewing Sarcoma With EWSR1-FLI1 GeneTranslocation Mimicking a Meningioma and a Multidisciplinary Therapeutic Approach: A Case Report and Systematic Review of Literatures
- Author:
Changjun HYUN
1
;
Yeonju LEE
;
Ho KANG
;
Hyun Joo PARK
;
Koung Jin SUH
;
Byung Se CHOI
;
Gheeyoung CHOE
;
Chae-Yong KIM
Author Information
- Publication Type:CASE REPORT
- From:Brain Tumor Research and Treatment 2023;11(4):281-288
- CountryRepublic of Korea
- Language:English
- Abstract: Ewing sarcoma and peripheral primitive neuroectodermal tumor (ES/pPNET) is an undifferentiated malignant tumor that is most prevalent in children and young adults and often radiologically mimics a meningioma. A 38-year-old female patient visited our hospital with complaints of right-sided tinnitus, right hemiparesis, and imbalance. She underwent preoperative imaging and was subsequently diagnosed as having a meningioma on the petrous ridge. After partial resection, EWSR1-FLI1 gene fusion was confirmed, and she was diagnosed with ES/pPNET. The tumor was successfully treated using a multidisciplinary approach of adjuvant chemo- and radiotherapy. This case is noteworthy because it is an extremely rare case of an intracranial ES/pPNET, and it is worth sharing our clinical experience that the tumor was successfully treated through a multidisciplinary therapeutic approach even though complete resection was not achieved.
