The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice.
- Author:
Ahmet ULUGOL
1
;
Hakan KARADAG
;
Dikmen DOKMECI
;
Ismet DOKMECI
Author Information
- Publication Type:Original Article
- Keywords: Compound 48/80; histamine; hypoxia; body temperature; histamine receptors
- MeSH: Animal; Anoxia/*drug therapy/physiopathology; Body Temperature/*drug effects; Convulsions/prevention & control; Male; Mice; Mice, Inbred BALB C; Receptors, Histamine H1/*physiology; Receptors, Histamine H2/*physiology; p-Methoxy-N-methylphenethylamine/*pharmacology
- From:Yonsei Medical Journal 1996;37(2):97-103
- CountryRepublic of Korea
- Language:English
- Abstract: Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.
