p53 protein expression in extrahepatic bile duct cancer.
10.3349/ymj.1996.37.2.112
- Author:
Yong Chan LEE
1
;
Si Young SONG
;
Jae Bock CHUNG
;
Jin Kyung KANG
;
In Suh PARK
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
p53 expression;
extrahepatic bile duct cancers
- MeSH:
Adult;
Aged;
Bile Duct Neoplasms/*chemistry/mortality;
*Bile Ducts, Extrahepatic;
Female;
Human;
Immunohistochemistry;
Male;
Middle Age;
Protein p53/*analysis/immunology;
Survival Rate
- From:Yonsei Medical Journal
1996;37(2):112-117
- CountryRepublic of Korea
- Language:English
-
Abstract:
p53 mutations, a tumor suppressor gene located on chromosome 17p, are the most common genetic alterations found in human cancers. Although the p53 expression or mutation has been investigated in a variety of cancers there have been very few studies in extrahepatic bile duct cancers. In this study, we investigated the immunohistochemical expression of p53 in formalin fixed paraffin embedded archival specimens of 36 extrahepatic bile duct cancers in which p53 expression was found in eighteen (50%) cases. There was no significant difference in age, gender, size of tumor, histologic grade, extent of tumor involvement, lymph node metastasis and tumor resectability according to p53 immunoreactivity. Comparison of survival duration according to p53 expression showed no significant difference. In conclusion, we reported 50 percent of p53 expression in extrahepatic bile duct cancers by immunohistochemical staining and we found no prognostic significance of p53 expression in dinicopathologic parameters.
