Whole lung lavage with granulocyte macrophage colony-stimulating factor inhalation in children with pulmonary alveolar proteinosis: A case report
10.4168/aard.2023.11.4.211
- Author:
Siyoon KIM
1
;
Min Jee PARK
;
Kun Baek SONG
;
Eom Ji CHOI
;
Eun Young PAEK
;
Dakyeong LEE
;
Soo-Jong HONG
Author Information
1. Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
- Publication Type:CASE REPORT
- From:Allergy, Asthma & Respiratory Disease
2023;11(4):211-215
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by hypoxemic respiratory failure due to the accumulation of lipoproteinaceous material in alveolar macrophages and alveoli. It has been reported that granulocyte macrophage colony-stimulating factor (GM-CSF) inhalation or whole lung lavage significantly improves the disease state. We present a case of 17-year-old female diagnosed with PAP and treated with both GM-CSF inhalation and whole lung lavage. Her symptoms, imaging findings, and pulmonary function tests improved after these treatments. Therefore, combined treatments of whole lung lavage and subsequent GM-CSF inhalation should be considered a treatment option for children and adolescents.
