Signal Transduction Mechanisms Mediating Surfactant Phospholipid Secretion in Isolated Type II Cell.
10.4046/trd.1996.43.2.123
- Author:
Sung Soo PARK
1
Author Information
1. Department of Pulmonary Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Review
- Keywords:
Signal transduction mechanisms;
Surfactant phospholipid secretion;
Isolated type II cell
- MeSH:
Adenosine Triphosphate;
Adenylyl Cyclases;
Cyclic AMP-Dependent Protein Kinases;
Diglycerides;
Inositol;
Negotiating*;
Phosphatidylcholines;
Phospholipids;
Protein Kinase C;
Signal Transduction*;
Type C Phospholipases
- From:Tuberculosis and Respiratory Diseases
1996;43(2):123-127
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Secretion of surfactant phospholipid can be stimulated by a variety of agonists acting via at least three different signal transduction mechanisms. These include the adenylate cyclase system with activation of cAMP-dependent protein kinase; activation of protein kinase C either directly or subsequent to activation of phosphoinositide-specific phospholipase C and generation of diacylglycerols and inositol trisphosphate; and a third mechanism that involves incresed Ca2+ levels and a calmodulin-dependent step. ATP stimulates secretion via all three mechanisms. The protein kinase C pathway is also coupled to phopholipase D which, acting on relatively abundant cellular phospholipids, generates diacylglycerols that further activate protein kinase C. Sustained protein kinase C activation can maintain phosphatidylcholine secretion for a prolonged period of time. It is likely that interactions between the different signaling pathways have an important role in the overall physiological regulation of surfactant secretion.
