Research progress on anti-pulmonary fibrosis effect and mechanism of flavonoids
- VernacularTitle:黄酮类成分抗肺纤维化的作用机制研究进展
- Author:
Yiting WANG
1
;
Weiwen PENG
1
;
Zhuqiang WANG
1
;
Liting HUANG
1
Author Information
1. Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine，Guangdong Zhongshan 528400，China
- Publication Type:Journal Article
- Keywords:
flavonoids;
pulmonary fibrosis;
mechanism
- From:
China Pharmacy
2023;34(23):2939-2944
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is the end-stage manifestation of a large class of lung diseases characterized by fibroblast proliferation and accumulation of a large amount of extracellular matrix accompanied by inflammatory injury and tissue structure destruction. Studies have shown that flavonoids have anti-pulmonary fibrosis effects through multiple paths， including dihydromyricetin， morin and fisetin can inhibit fibroblast differentiation； Trollius altaicus flavonoids， hesperidin and linarin can play an anti-inflammatory role； total flavonoids from Scutellaria baicalensis， scutellarin and chrysin can inhibit epithelial- mesenchymal transition； total flavonoids of Litchi chinensis， diosmin and silybin can play an anti-oxidative stress role； quercetin， baicalin and apigenin can regulate autophagy； total flavonoids of Oxytropis falcata， calycosin and dihydroquercetin can regulate apoptosis； naringin， scutellarin and total flavonoids of Dracocephalum moldavica can inhibit pyroptosis， thus exerting anti- pulmonary fibrosis effects.
