Research progress on the intervention of traditional Chinese medicine monomer and formula in the mTOR signaling pathway for the treatment of osteoporosis
- VernacularTitle:中药单体及复方干预mTOR信号通路治疗骨质疏松症的研究进展
- Author:
Yan CHEN
1
,
2
;
Liufeng SHAN
3
;
Wensheng CHE
4
;
Yujun LIU
2
;
Zhiqi LIU
2
;
Xiaoxue SHI
2
;
Zhihai FENG
1
Author Information
1. Dept. of Endocrinology，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
2. First College of Clinical Medicine，Henan University of Chinese Medicine，Zhengzhou 450003，China
3. Dept. of Diabetes，Zhengzhou Hospital of TCM，Zhengzhou 450006，China
4. Dept. of TCM，Zhengzhou People’s Hospital，Zhengzhou 450053，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
monomer;
formula;
osteoporosis;
mTOR signaling pathway
- From:
China Pharmacy
2023;34(23):2934-2938
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is an important cause of bone weakness and susceptibility to fractures. Anti-osteoporosis drugs of Western medicine cannot reverse its progression， and can only reduce the loss of bone density； long-term use of them is accompanied by certain adverse reactions. Traditional Chinese medicine focuses on syndrome differentiation and holistic approach， which can make up for the shortcomings of Western medicine’s treatment. The mammalian target of rapamycin （mTOR） signaling pathway is involved in the growth， proliferation， and differentiation of bone cells， and is closely related to the occurrence and development of osteoporosis. In recent years， various traditional Chinese medicine monomers （such as flavonoids， polysaccharides， alkaloids， etc.） and traditional Chinese medicine formulas （such as Bushen huoxue decoction， Liuwei dihuang pills， Erzhi pills， etc.） have been proven to promote bone formation， inhibit bone resorption， enhance bone cell autophagy， and delay the progression of osteoporosis by regulating the mTOR signaling pathway. Therefore， the article summarizes the traditional Chinese medicine monomer and formula that intervene in the mTOR signaling pathway for the treatment of osteoporosis， in order to provide medication ideas for the traditional Chinese medicine treatment of osteoporosis.
