Pharmacological Effect of Phellodendri Chinensis Cortex and Active Components on Gout： A Review
10.13422/j.cnki.syfjx.20231119
- VernacularTitle:川黄柏及其活性成分治疗痛风病作用研究进展
- Author:
Min LI
1
;
Yunyun QUAN
2
;
Ting WANG
2
;
Li LI
2
;
Jin ZENG
2
;
Junning ZHAO
1
;
Jiuzhou MAO
2
;
Yangfan TANG
2
;
Zhujun YIN
2
Author Information
1. School of Pharmacy， Chengdu University of Traditional Chinese Medicine（TCM）， Chengdu 610075， China
2. Sichuan Academy of Chinese Medicine Sciences， Sichuan Center for Translational Chinese Medicine， Key Laboratory of Biological Evaluation of Quality of TCM， State Administration of TCM， Sichuan Key Laboratory of Translational Chinese Medicine， Sichuan Engineering Technology Research Center of Genuine Regional Drug， Sichuan Provincial Engineering Research Center of Formation Principle and Quality Evaluation of Genuine Medicinal Materials， Chengdu 610041， China
- Publication Type:Journal Article
- Keywords:
gout;
Phellodendri Chinensis Cortex;
active components;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(1):286-298
- CountryChina
- Language:Chinese
-
Abstract:
Gout is a metabolic disease closely associated with hyperuricemia and urate deposition. Because of the complex pathogenesis， high morbidity， multiple complications， and increasingly young patients， gout has received worldwide attention. Currently， western medicine mainly treats gout by lowering the uric acid level and reducing inflammation， which， however， causes serious adverse reactions and has contraindications. Phellodendri Chinensis Cortex （PCC） is the dried bark of Phellodendron chinense， with the effects of clearing heat， drying dampness， purging fire， detoxifying， and treating sores. Studies have shown that PCC and its active components have anti-inflammatory， pain-relieving， uric acid-lowering， and anti-gout activities， with extensive sources and high safety. PCC and its active components could prevent and treat gout through multi-targets and multi-pathways， whereas the systematic review remains to be carried out. Therefore， this paper summarized the pharmacological activities and mechanisms of PCC and its active components in the treatment of gout. The available studies have shown that PCC and its active components exert the anti-gout effect by lowering the uric acid level， reducing inflammation， alleviating oxidative stress， and regulationg intestinal flora， and protecting the kidneys. Particularly， the active components represented by alkaloids contribute obviously to the therapeutic effect of of PCC. Herein， we analyzed the problems and future development of the research on PCC， aiming to provide theoretical support and a scientific basis for the research and development of new drugs against gout.
