Total Saponins in Paridis Rhizoma： A Review
10.13422/j.cnki.syfjx.20232125
- VernacularTitle:重楼总皂苷的现代研究进展与展望
- Author:
Yibo ZHANG
1
;
Huizhong ZHANG
1
;
Jing FU
2
;
Yidan RUAN
1
;
Aina YAO
1
;
Pingzhi ZHANG
1
;
Xingbin YIN
1
;
Changhai QU
1
;
Jian NI
1
;
Xiaoxu DONG
1
Author Information
1. School of Chinese Material Medica， Beijing University of Chinese Medicine， Beijing 102488， China
2. Beijing Institute of Chinese Medicine， Beijing Hospital of Traditional Chinese Medicine， Capital Medical University， Beijing 100010， China
- Publication Type:Journal Article
- Keywords:
total saponins in Paridis Rhizoma;
antitumor effect;
pharmacological effect;
pharmacokinetics;
adverse reaction
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(1):232-243
- CountryChina
- Language:Chinese
-
Abstract:
Paridis Rhizoma possesses the functions of clearing heat and detoxifying， alleviating swelling and relieving pain， cooling the liver and calming the convulsion. Saponins are the main active components of Paridis Rhizoma. Studies have shown that total saponins in Paridis Rhizoma have obvious inhibitory effect on solid tumors such as breast cancer， lung cancer， gastric cancer， and liver cancer and non-solid tumors such as leukemia. The saponins may exert the anti-tumor effects by inhibiting the proliferation， migration， and invasion of tumor cells， regulating cell cycle， inducing apoptotic and non-apoptotic death pathways， and regulating metabolism and tumor microenvironment. Furthermore， total saponins in Paridis Rhizoma showed anti-inflammatory， antioxidant， antimicrobial， hemostatic， and uterus-contracting activities. At the same time， they may induce apoptosis of normal cells， inflammation and oxidative stress， and metabolic disorders. In recent years， the reports of liver injury， reproductive injury， gastrointestinal injury， hemolysis， and other adverse reactions caused by total saponins in Paridis Rhizoma have been increasing. Pharmacokinetic studies have shown that there are significant differences in the metabolism of total saponins in Paridis Rhizoma administrated in different ways. Injection has a fast clearance rate， while oral administration may have hepatoenteric circulation. Meanwhile， due to the low solubility and activation of P-glycoprotein （P-gp） molecular pump， the prototype absorption， intestinal permeability， and recovery rate of total saponins in Paridis Rhizoma are poor， which affects the bioavailability. The bioavailability can be improved to some extent by preparing new dosage forms or new drug delivery systems with advanced technology. This paper reviews the pharmacological effect， pharmacokinetics， and adverse reactions of Rhizoma Paridis total saponins by searching the China National Knowledge Infrastructure （CNKI）， VIP， and Web of Science with ''Rhizoma Paridis total saponins'' as the keywords， hoping to provide references for the research， development， and clinical application of such components.
