Remyelination Regulated by microRNAs in Neurodegenerative Diseases： A Review

Manjing LI; Qi LI; Qingsen Ran; Kunni Chen; Xinke DU; Lina Yang; Chunxia Nie; Qing Yang; Yujie LI; Ying Chen; Yajie Wang; Xiaogang Weng; Weiyan Cai; Xiaoxin Zhu

Return

Remyelination Regulated by microRNAs in Neurodegenerative Diseases： A Review

VernacularTitle:神经退行疾病中髓鞘再生及microRNA的调控机制
Author: Manjing LI ¹ ; Qi LI ¹ ; Qingsen RAN ¹ ; Kunni CHEN ² ; Xinke DU ¹ ; Lina YANG ¹ ; Chunxia NIE ¹ ; Qing YANG ¹ ; Yujie LI ¹ ; Ying CHEN ¹ ; Yajie WANG ¹ ; Xiaogang WENG ¹ ; Weiyan CAI ¹ ; Xiaoxin ZHU ¹
Author Information

1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
2. Xuanwu Traditional Chinese Medicine Hospital Beijing，Beijing 100050，China
Publication Type:Review
Keywords: microRNA; remyelination; multiple sclerosis; degenerative diseases; oligodendrocyte
From: Chinese Journal of Experimental Traditional Medical Formulae 2024;30(1):223-231
CountryChina
Language:Chinese
Abstract: Demyelination of the central nervous system often occurs in neurodegenerative diseases， such as multiple sclerosis （MS）. The myelin sheath， a layer of myelin membrane wrapping the axon， plays a role in the rapid conduction and metabolic coupling of impulses for neurons. The exposure of the axon will lead to axonal degeneratio， and further neuronal degeneration， which is the main cause of dysfunction and even disability in patients with demyelinating neurodegenerative diseases. In addition to the demyelination of mature myelin sheath， remyelination disorder is also one of the major reasons leading to the development of the diseases. The myelin sheath is composed of oligodendrocytes （OLs） derived from oligodendrocyte progenitor cells （OPCs） which are differentiated from neural stem cells （NSCs）. The process of myelin regeneration， i.e.， remyelination， is the differentiation of NSCs into OLs. Recent studies have shown that this process is regulated by a variety of genes. MicroRNAs， as important regulators of neurodegenerative diseases， form a complex regulatory network in the process of myelin regeneration. This review summarizes the main molecular pathways of myelin regeneration and microRNAs involved in this process and classifies the mechanisms and targets. This review is expected to provide a theoretical reference for the future research on the treatment of demyelinating diseases by targeting the regulation of microRNAs.