Compatibility Theory of Yiqi Zengmian Prescription as Vaccine Adjuvant
10.13422/j.cnki.syfjx.20231513
- VernacularTitle:疫苗佐剂“益气增免方”组方配伍理论探析
- Author:
Xinyi GU
1
;
Lin TONG
2
;
Shihuan TANG
3
;
Hui LI
4
;
Ruili HUO
5
Author Information
1. Experimental Research Center， China Academy of Chinese Medical Sciences， Beijing 100700， China
2. Institute of Information on Traditional Chinese Medicine （TCM）， China Academy of Chinese Medical Sciences， Beijing 100700， China
3. Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700， China
4. Institute of TCM Health Industry， China Academy of Chinese Medical Sciences， Beijing 100700， China
5. China Academy of Chinese Medical Sciences， Beijing 100700， China
- Publication Type:Journal Article
- Keywords:
vaccine adjuvants;
Yiqi Zengmian prescription;
severe acute respiratory syndrome coronavirus-2（SARS-CoV-2）;
compatibility of prescriptions
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(1):208-215
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThis study explored the application of Yiqi Zengmian prescription as a vaccine adjuvant， aiming to provide a new scheme for the prevention and control of corona virus disease 2019（COVID-19） with traditional Chinese medicine （TCM）. By analyzing the compatibility and efficacy， this paper examines the compatibility effect of Yiqi Zengmian prescription， which is modified from the classic tonifying agent Si Junzitang， as a vaccine adjuvant. MethodUsing the Database of Ancient Classical Prescriptions， this paper analyzed the composition of Yiqi Zengmian prescription and probed into the theoretical basis for the compatibility of this prescription from the properties， medicine combination， and efficacy. Furthermore， the compatibility effect of this prescription with vaccines was analyzed. ResultAs a TCM prescription， Yiqi Zengmian prescription focuses on the lung and spleen and enhances the Qi in the two organs. The lung governs Qi movement. The body breathes fresh air through the lungs and exchanges the turbid gas in the lungs， and the gas circulates alternately in the lungs to ensure the normal breathing of the human body. The spleen governing transportation and transformation is the hub for Qi movement， and Qi is the embodiment of metabolic function. By regulating qi movement and enhancing the functions of Qi and blood， Yiqi Zengmian prescription can enhance the immunogenicity of the vaccine， which provides a theoretical basis for enhancing the immune effects of vaccines. ConclusionYiqi Zengmian prescription has the effects of replenishing Qi and invigorating spleen， regulating Qi and drying dampness， and enhancing immunity. The in-depth analysis of the TCM theory of Yiqi Zengmian prescription as a vaccine adjuvant and the results of clinical and laboratory studies suggest that Yiqi Zengmian prescription may enhance the induction of immune response after vaccination and maintain the immune memory. However， the mechanism of Yiqi Zengmian prescription in regulating the complex immune network remains to be elucidated.
