History and Clinical Application of Classic Famous Formula Danggui Sinitang
10.13422/j.cnki.syfjx.20232322
- VernacularTitle:经典名方当归四逆汤的历史沿革与关键信息考证
- Author:
Sihong LIU
1
;
Siqi JIA
2
;
Lin TONG
1
;
Li REN
3
;
Lei ZHANG
1
;
Lei YANG
4
;
Yanhui KUANG
3
;
Deqin WANG
3
;
Bing LI
5
;
Huamin ZHANG
4
Author Information
1. Institute of Information on Traditional Chinese Medicine （TCM），China Academy of Chinese Medical Sciences，Beijing 100700，China
2. Hebei University of Chinese Medicine，Shijiazhuang 050200，China
3. Guangzhou Baiyunshan Heji Huangpu TCM Co.Ltd.，Guangzhou 510000，China
4. Institute of Basic Theory of TCM，China Academy of Chinese Medical Sciences，Beijing 100700，China
5. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
classic famous formula;
Danggui Sinitang;
textual research;
key information;
clinical application
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(1):53-60
- CountryChina
- Language:Chinese
-
Abstract:
Danggui Sinitang is first recorded in the Treatise on Cold Damage written by ZHANG Zhongjing in the Han dynasty. It is composed of Angelicae Sinensis Radix， Cinnamomi Ramulus， Paeoniae Radix Alba， Asari Radix et Rhizoma， Glycyrrhizae Radix et Rhizoma， Tetrapanacis Medulla， and Jujubae Fructus and serves as a classic formula for treating the syndrome of blood deficiency and cold reversal. This study systematically reviews the records of Danggui Sinitang in ancient Chinese medicine books of various dynasties and the modern clinical applications to probe into the composition， plant species， processing， dosage， decocting method， and indications of Danggui Sinitang， aiming to provide a reference for the development and clinical application of this classic formula. The review of the records showed that there were a variety of records of Danggui Sinitang with different composition， and the composition of this formula listed in the Treatise on Cold Damage has a significant impact on later generations and has been used by medical practitioners throughout history. Although the dosage of some drugs decreased during the Ming and Qing dynasties， the medical practitioners continued to use the original formula. In terms of processing， although there were slight changes in the processing of Angelicae Sinensis Radix， Paeoniae Radix Alba， Glycyrrhizae Radix et Rhizoma， and Tetrapanacis Medulla， the original processing method was inherited. In terms of indications， Danggui Sinitang was designed to treat cold reversal due to blood deficiency and dysentery. Furthermore， it was used to treat headache， convulsive disease， infantile convulsion， and private part adduction in the Ming and Qing dynasties. Nowadays， this formula is mostly used to treat diabetes peripheral neuropathy， rheumatoid arthritis， dysmenorrhea， Raynaud's disease and other diseases. In terms of precautions， ancient physicians believed that Danggui Sinitang should not be taken by pregnant women and should only be used for limb chills caused by blood deficiency and cold coagulation. For limb chills caused by other reasons， this formula should not be used indiscriminately. Modern research has not reported any serious adverse reactions related to this formula. Danggui Sinitang has a definite therapeutic effect. In subsequent research and development， quality control standards of Danggui Sinitang should be established while its safety is ensured， and the related preparations should be developed and applied.
