Subcellular localization of macrophage migration inhibitory factor and its diverse biological functions in tumors
10.16438/j.0513-4870.2023-0623
- VernacularTitle:不同亚细胞定位的巨噬细胞迁移抑制因子促肿瘤功能研究进展
- Author:
Huan ZHANG
;
Chen YANG
;
Shuang SHANG
;
Xiao-xi LV
;
Fang HUA
- Publication Type:Research Article
- Keywords:
macrophage migration inhibitory factor;
subcellular localization;
tumor;
tumor microenvironment;
targeted therapy
- From:
Acta Pharmaceutica Sinica
2023;58(8):2085-2097
- CountryChina
- Language:Chinese
-
Abstract:
Macrophage migration inhibitory factor (MIF) is an enzyme-active pleiotropic cytokine that is expressed in various immune cells and tumor cells. MIF plays diverse roles in inflammation and tumor progression. It acts as a cytokine involved in immune response and inflammatory lesions. Additionally, MIF is closely associated with tumor proliferation, metastasis, and other tumor hallmarks, exerting a multifaceted influence on tumor occurrence and progression. MIF not only functions by being secreted into the extracellular space as a cytokine but can also be localized within the cytoplasm and nucleus, exhibiting diverse biological functions. As MIF in promoting tumor progression becomes increasingly recognized, MIF-based therapeutic strategies have become a hot research topic in oncology. Here, we provide a comprehensive review of MIF with different subcellular localization about their pro-tumoral functions. A better understanding of MIF in tumor biology will bring broader perspectives for the development of novel MIF targeting strategies and give promising direction for future tumor treatments.
