Recent advances in chemical fluorescent probes sensitive to tumor microenvironments
10.16438/j.0513-4870.2023-0590
- VernacularTitle:肿瘤微环境敏感型化学荧光探针的研究进展
- Author:
Ke-liang LI
1
;
Yang LIU
2
;
Chun-yang LOU
1
;
Tian-le HUANG
1
;
Zhan-ying HONG
1
;
Shan-chao WU
1
;
Chun-quan SHENG
1
Author Information
1. The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China
2. Department of Pharmacy, No. 971 Hospital of the People's Liberation Army Navy, Qingdao 266071, China
- Publication Type:Research Article
- Keywords:
tumor;
tumor microenvironment;
theranostics;
chemical fluorescent probe
- From:
Acta Pharmaceutica Sinica
2023;58(8):2180-2192
- CountryChina
- Language:Chinese
-
Abstract:
Cancer seriously threatens human life and health, it is urgent for the development of rapid detection, precise localization and effective treatment of tumors. Chemical fluorescent probes that are sensitive to tumor-specific microenvironments have important significance in tumor theranostics and a variety of such probes have been developed. In this review, we classified chemical fluorescent probes that are sensitive to tumor microenvironments according to biological characteristics and microenvironmental changes while combining spectroscopy or response mechanisms, and systematically introduced the research progress of chemical fluorescent probes with sensitivity to hypoxia, low polarity, high viscosity, abnormal pH values and abundant reactive oxygen species in tumor microenvironments, in order to provide references for the development and applications of these probes.
