Research progress of biomimetic nano drug delivery system in nervous system disease

VernacularTitle:仿生型纳米药物递送系统在神经系统疾病中的研究进展
Author: Chen-fei LIU ; Cong-cong XIAO ; Yan-hong LIU ; Li-qing CHEN ; Chao LIU ; He-ming ZHAO ; Ming-ji JIN ; Zhong-gao GAO ; Wei HUANG
Publication Type:Research Article
Keywords: biomimetic; nano drug delivery system; central nervous system disease; blood brain barrier
From: Acta Pharmaceutica Sinica 2023;58(8):2300-2310
CountryChina
Language:Chinese
Abstract: Brain delivery of drugs remains challenging due to the presence of the blood-brain barrier (BBB). With advances in nanotechnology and biotechnology, new possibilities for brain-targeted drug delivery have emerged. Biomimetic nano drug delivery systems with high brain-targeting and BBB-penetrating capabilities, along with good biocompatibility and safety, can enable 'invisible' drug delivery. In this review, five different types of biomimetic strategies are presented and their research progress in central nervous system disorders is reviewed. Finally, the challenges and future prospects for biomimetic nano drug delivery systems in intracerebral drug delivery are summarized.