Recent advances of antiviral drugs based on multispecific binding strategy
10.16438/j.0513-4870.2023-0539
- VernacularTitle:基于多特异性结合策略的抗病毒药物研究进展
- Author:
Yang ZHOU
;
Shu-jing XU
;
Dang DING
;
Shuo WANG
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
virus;
multispecific binding strategy;
antiviral drug;
medicinal chemistry;
rug design
- From:
Acta Pharmaceutica Sinica
2023;58(8):2203-2217
- CountryChina
- Language:Chinese
-
Abstract:
To address the continuous emergence of drug-resistant strains of viruses and the outbreaks of novel virus infections, developing new antiviral drugs based on novel strategies has become an important and urgent research topic. In recent years, the rapidly developing multi-specific binding strategy has become a focus and been widely applied in antiviral. This review summarizes the recent progress of the multi-specific binding strategy in the antiviral field from the perspective of medicinal chemistry and discusses existing challenges as well as future opportunities for antiviral drug discovery.
