Transdermal drug delivery technology for brain-targeted drug delivery

VernacularTitle:经皮给药技术用于脑靶向药物递送
Author: Chen-xi YU ; Hui-le GAO
Publication Type:Research Article
Keywords: transdermal drug delivery; nano-delivery system; brain disease; blood-brain barrier; lymphatic pathway
From: Acta Pharmaceutica Sinica 2023;58(8):2334-2340
CountryChina
Language:Chinese
Abstract: Intracerebral delivery of drugs for the treatment of central nervous system disorders is usually limited by the blood-brain barrier (BBB). Transdermal drug delivery systems (TDDS) have the advantage of improving patient compliance and avoiding first-pass effects compared to intravenous, oral and intranasal drug delivery, and are an emerging non-invasive drug delivery route that facilitates long-term drug delivery to patients. The discovery of direct subcutaneous targeting of lymphatic pathways to brain tissue has made TDDS a new brain-targeted drug delivery strategy. At the same time, the development of nano-delivery technology has further facilitated the application of TDDS for targeted drug delivery to the brain. This review summarizes the mechanism of transdermal drug delivery into the brain and the application of TDDS in the treatment of brain diseases, providing new ideas and methods for the treatment of central nervous system diseases.