Research progress of intestinal microecological disorders caused by antibiotics and the treatment
10.16438/j.0513-4870.2022-1381
- VernacularTitle:抗生素引起肠道微生态紊乱及其治疗的研究进展
- Author:
Xiang-yin CHI
;
Yuan LIN
;
Jian-dong JIANG
- Publication Type:Research Article
- Keywords:
antibiotics;
intestinal microecology;
gut microbiota;
colonization resistance;
treatment
- From:
Acta Pharmaceutica Sinica
2023;58(8):1981-1987
- CountryChina
- Language:Chinese
-
Abstract:
There is a variety of gut microbiota in human body, which is closely associated with the health and disease. Normal gut microbiota can produce colonization resistance to pathogens. Antibiotics can affect the composition of gut microbiota and change the intestinal microenvironment, resulting in intestinal microecological disorders, which in turn cause intestinal pathogenic infections and other diseases. In this paper, the concept of intestinal microecology, the mechanism of intestinal colonization resistance, the effect of antibiotics on intestinal microecology, and the treatment methods were reviewed, aiming to provide the information for the rational use of antibiotics and the development of more effective treatment methods to maintain the stability of intestinal microecology.
