Pyridine pigments from functional Monascus rice
10.16438/j.0513-4870.2022-1191
- VernacularTitle:功能红曲米中的吡啶类色素化合物
- Author:
Bing-yu LIU
;
Xiao-ming ZHENG
;
An-an LIU
;
Fei XU
;
Qian WEI
;
You-cai HU
- Publication Type:Research Article
- Keywords:
italic>Monascus rice;
pigment;
molecular docking;
peroxisome proliferators-activated receptor-gamma agonist;
biosynthesis
- From:
Acta Pharmaceutica Sinica
2023;57(8):2442-2447
- CountryChina
- Language:Chinese
-
Abstract:
The trace chemical components in functional Monascus rice were studied to explore the potential bioactive substances. MCI column, Sephadex LH-20 gel, and preparative liquid chromatography were used to purified the ethyl acetate extract from functional Monascus rice. Two novel pyridine Monascus pigments were isolated and identified, named monascopyridine G (1) and monascopyridine H (2), respectively based on extensive mass spectrometry (MS), infrared radiation (IR), and nuclear magnetic resonance (NMR) analysis. The molecular docking experiments between compounds 1 and 2 and peroxisome proliferators-activated receptor-gamma (PPARγ) showed that they exhibited obvious binding force with the receptor protein. Besides, the biosynthetic pathways of the two compounds were proposed, which provide a valuable reference for the selective production of these potential bioactive substances.
