Stability and taste evaluation of two kinds of oral solvent after extemporaneous compounding
10.16438/j.0513-4870.2023-0535
- VernacularTitle:两种口服溶剂介质临时调配后的稳定性考察及口感评价
- Author:
Wei-wei GUAN
1
;
Min HUANG
2
;
Huan ZHANG
1
;
Long-tai YOU
1
;
Li-ping FENG
2
;
Min YANG
2
;
Dong MEI
1
;
Xiao-ling WANG
1
Author Information
1. Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
2. Zhejiang Beiling Biological Medicine Co., Ltd., Hangzhou 311203, China
- Publication Type:Research Article
- Keywords:
extemporaneous compounding;
oral solvent;
stability;
taste evaluation;
children
- From:
Acta Pharmaceutica Sinica
2023;58(11):3198-3203
- CountryChina
- Language:Chinese
-
Abstract:
A flavoring agent and a suspension agent were prepared for extemporaneous compounding. The stability of the two agents before and after drug loading was investigated, and the taste of the suspension after extemporaneous compounding was evaluated by electronic tongue technology. The two agents remained stable under the conditions of influence factor test, accelerated test and long-term test. The appearance properties of the two agents did not change. The relative density of the flavoring agent was maintained at 1.053-1.075, and the pH was stable at 4.2-4.5. The relative density of the suspension agent was maintained at 0.999-1.022, and the pH was stable at 4.0-4.5. Seven kinds of drugs, including warfarin sodium tablets and spironolactone tablets, were mixed with these two oral solvents, and the content uniformity and stability were detected respectively. The results showed that the preparations could be evenly dispersed and the physical and chemical properties were stable. The results of taste evaluation showed that in captopril group and chloral hydrate group, the flavoring agent had the best effect on taste correction. In warfarin sodium group, rifampicin group, spironolactone group, vitamin B1 group and vitamin B2 group, the blending agents had the best effect on taste correction.
