Formulation optimization and analysis of taste-masking effect of licorzine granules based on sensory evaluation and electronic tongue method
10.16438/j.0513-4870.2023-0408
- VernacularTitle:基于感官评价和电子舌法的甘草锌颗粒处方筛选与掩味作用分析
- Author:
Li-min WANG
1
;
Shu-ye QI
2
;
Wei-feng ZHANG
1
,
3
;
Peng SHEN
1
;
Bao-ming NING
2
;
Da-yong SHI
1
;
Xue-ping WU
1
;
Jie YANG
1
,
3
Author Information
1. Shandong DYNE Marine Biopharmaceutical Co., Ltd., Weihai 264300, China
2. National Institutes for Food and Drug Control, Beijing 102629, China
3. Beijing DYNE High-tech Pediatric Pharmaceutical R＆D Institute Co., Ltd., Beijing 100176, China
- Publication Type:Research Article
- Keywords:
licorzine;
licorzine granule;
sensory evaluation;
electronic tongue;
formulation optimization;
taste-masking;
xanthan gum
- From:
Acta Pharmaceutica Sinica
2023;58(11):3191-3197
- CountryChina
- Language:Chinese
-
Abstract:
Licorzine granules are common preparations for children zinc deficiency. Considering the long course of treatment, the taste of licorzine granules may become a main factor affecting medication adherence. To date there have been no taste evaluation research into licorzine granules yet. In this study, both sensory evaluation and electronic tongue method were utilized to optimize licorzine granules formulations, evaluate the tastes of licorzine, excipients, optimized formulation in vivo and in vitro. As the results show, bitterness and astringency are the main unpleasant tastes generating from licorzine. Xanthan gum is the main taste-masking excipient, lowering down the bitterness and astringency of licorzine by at least one grade. Good correlation exists between the results of sensory evaluation and electronic tongue method, and an integrated combination of the two helps to obtain objective and rational research conclusions. The adult sensory evaluation study was a research-based clinical trial conducted with informed consent from all subjects in accordance with the ethical requirements of Good Clinical Practice.
