Anti-aging and mechanism of 2-O-cinnamic acid magnolol
10.16438/j.0513-4870.2023-0224
- VernacularTitle:2-O-肉桂酸厚朴酚抗衰老及机制研究
- Author:
Xin-xin PANG
1
;
Jun YANG
2
;
Hong-liu YANG
1
;
Xiao-xiao FAN
1
;
Tao MA
1
;
Yong-gang LIU
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
2. Beijing Tede Pharmaceutical Co., Ltd., Beijing 100176, China
- Publication Type:Research Article
- Keywords:
magnolol;
magnolol derivative;
lifespan;
anti-aging;
antioxidant;
italic>Caenorhabditis elegans
- From:
Acta Pharmaceutica Sinica
2023;58(11):3321-3329
- CountryChina
- Language:Chinese
-
Abstract:
Magnolol, a hydroquinone containing an allyl side chain, is one of the major active components of magnolia for antioxidation and anti-aging. To enhance the anti-aging activity and improve the intramolecular hydrogen bonding of magnolol, magnolol was reacted with cinnamic acid to obtain 2-O-cinnamic acid magnolol by esterification. The anti-aging activity of magnolol 2-O-cinnamate was investigated based on Caenorhabditis elegans model. The results showed that 2-O-cinnamic acid magnolol can reduce lipofuscin accumulation in the nematode body, and the effect is better than that of magnolol. 2-O-Cinnamic acid magnolol can extend nematode lifespan, reduce ROS levels in nematodes during normal aging and oxidative stress and improve nematode stress resistance under heat stress and oxidative stress. 2-O-Cinnamic acid magnolol could induce DAF-16 translocation from the cytoplasm to the nucleus and upregulate the expression of the sod-3 gene encoding superoxide dismutase in the nematode TJ356 expressing DAF-16 fused with GFP. 2-O-Cinnamic acid magnolol did not improve the survival rate of hsp-16.2 gene deficient nematodes under oxidative stress, indicating that 2-O-cinnamic acid magnolol improves stress resistance of nematodes under oxidative stress may be associated with sod-3 and hsp-16.2. Moreover, 2-O-cinnamic acid magnolol did not extend the lifespan of daf-16 and age-1 mutants, indicating that age-1 and daf-16 are required for 2-O-cinnamic acid magnolol to delay aging. It showed that magnolol 2-O-cinnamic acid has the potential to improve antioxidant capacity and delay aging, and the mechanism may be related to the insulin/insulin-like growth factor signaling pathway.
