Recent advances of small molecule inhibitors directly targeting HBV
10.16438/j.0513-4870.2023-0111
- VernacularTitle:直接靶向HBV的小分子抑制剂研究进展
- Author:
Jia-hui ZHOU
;
Shuo WANG
;
Dang DING
;
Xiang-rui XU
;
Shu-jing XU
;
Yong HE
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
Hepatitis B virus;
inhibitor;
rug target;
medicinal chemistry;
rug design
- From:
Acta Pharmaceutica Sinica
2023;58(11):3270-3284
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus infection is a serious threat to human life and health. The approved anti-HBV drugs including interferons and nucleos(t)ide analogues have serious adverse effect, rebound phenomena after drug withdrawal, and drug resistance. And the cccDNA cannot be completely eliminated by both of them, which is the reason why a complete cure for hepatitis B cannot be achieved. Therefore, developing anti-HBV drugs directly targeting protein or nucleic acid of HBV remains a current public health priority. Based on the analysis of representative literature from the last decade, this article reviews recent developments in small molecule inhibitors directly targeting HBV from a medicinal chemistry perspective.
