Recent advances in small-molecule inhibitors targeting influenza virus glycoproteins
10.16438/j.0513-4870.2023-0109
- VernacularTitle:靶向流感病毒表面糖蛋白的小分子抑制剂研究进展
- Author:
Yuan-min JIANG
;
Ji-wei ZHANG
;
Rui-fang JIA
;
Hui-nan JIA
;
Ying ZHANG
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
influenza virus;
neuraminidase;
hemagglutinin;
rug design;
small-molecule inhibitor
- From:
Acta Pharmaceutica Sinica
2023;58(11):3254-3269
- CountryChina
- Language:Chinese
-
Abstract:
Hemagglutinin and neuraminidase, two important glycoproteins on the surface of influenza virus, play a considerable role in the entry and release stage of the viral life cycle, respectively. With in-depth investigation of influenza virus glycoproteins and the continuous innovation of drug discovery strategies, a new generation of glycoproteins inhibitors have been continuously discovered. From the point of view of medicinal chemistry, this review summarizes the current advances in seeking small-molecule inhibitors targeting influenza virus glycoproteins, hoping to provide valuable guidance for future development of novel antiviral drugs.
