One new glycoside naphthopyranone from the Yiling cave-derived Metarhizium anisopliae NHC-M3-2
10.16438/j.0513-4870.2023-0346
- VernacularTitle:伊岭岩溶洞真菌Metarhizium anisopliae NHC-M3-2中一个新的萘并吡喃酮糖苷
- Author:
Li-man ZHOU
;
Yi HAO
;
Ju-xiang MENG
;
Fang-fang QIN
;
Qing-hua QIN
;
Cong WANG
;
Fan-dong KONG
- Publication Type:Research Article
- Keywords:
cave-derived Metarhizium anisopliae NHC-M3-2;
secondary metabolite;
glycoside compound;
anti-hepatitis B activity
- From:
Acta Pharmaceutica Sinica
2023;58(10):3076-3081
- CountryChina
- Language:Chinese
-
Abstract:
Seven compounds were isolated from fermentation extract of cave-derived Metarhizium anisopliae NHC-M3-2 by silica gel, semi-preparative HPLC and other chromatographic methods. Their structures were elucidated by UV, IR, MS and NMR methods as 2,3-dehydroindigotide G (1), (-)-regiolone (2), naphtho-γ-pyrone (3), indigotide G (4), indigotide B (5) destruxin A (6) and destruxin B (7). Compound 1 is a new glycoside naphthopyranone compound. The anti-hepatitis B virus (HBV) activity of these compounds was evaluated. The EC50 and CC50 of compound 3 against HBV were 4.5 μmol·L-1 and 92.3 μmol·L-1, respectively. This is the first report of the antiviral activity of compound 3.
